1200014M14Rik Inhibitors
Chemical inhibitors of 1200014M14Rik function by disrupting various signaling pathways that are essential for its activity. Wortmannin and LY294002, for instance, target phosphoinositide 3-kinases (PI3K), leading to a blockade in PI3K-dependent pathways that regulate 1200014M14Rik. Similarly, Rapamycin exerts its inhibitory effect by binding to FKBP12 and inhibiting the mTOR pathway, which is also crucial for 1200014M14Rik function. These inhibitors collectively prevent the activation and function of 1200014M14Rik by interfering with upstream signaling components necessary for its regulation.
Other inhibitors, such as PD98059 and U0126, affect the MAPK/ERK pathway. PD98059 inhibits MEK, while U0126 is a selective inhibitor for both MEK1 and MEK2, suppressing ERK phosphorylation. By doing so, they limit the activation of signaling cascades that contribute to the functional state of 1200014M14Rik. Similarly, SB203580 and SP600125 target p38 MAP Kinase and c-Jun N-terminal kinase (JNK), respectively, which are part of different signaling pathways but ultimately impact the activity of 1200014M14Rik. Further, Go6983 and Bisindolylmaleimide I, as inhibitors of PKC, and PP2, as an inhibitor of Src family kinases, prevent the phosphorylation events that are typically required for 1200014M14Rik activity. Y-27632 disrupts the Rho-associated protein kinase (ROCK) pathway, affecting actin cytoskeleton dynamics and cellular processes involving 1200014M14Rik. Lastly, Staurosporine, a broad-spectrum protein kinase inhibitor, targets multiple kinases that could potentially activate 1200014M14Rik, thus serving as a powerful inhibitor of its activity.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
As an inhibitor of phosphoinositide 3-kinases (PI3K), Wortmannin can lead to the inhibition of 1200014M14Rik by disrupting PI3K-dependent signaling pathways which are crucial for the activity and regulation of this protein. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
By binding to FKBP12 and inhibiting mTOR, Rapamycin impedes downstream signaling pathways that are essential for the activity of 1200014M14Rik, leading to its functional inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
This chemical inhibits PI3K, leading to a blockade of the AKT signaling pathway. Since AKT pathway is involved in regulating the activity of 1200014M14Rik, LY294002's action results in the functional inhibition of the protein. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 inhibits MEK, which is part of the MAPK/ERK pathway. By inhibiting this pathway, PD98059 suppresses the downstream signaling that contributes to the functional activity of 1200014M14Rik. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of both MEK1 and MEK2, which leads to the suppression of ERK phosphorylation. This inhibition downregulates the signaling pathways that are necessary for the functional activity of 1200014M14Rik. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
As an inhibitor of p38 MAP Kinase, SB203580 interferes with the signaling pathways that lead to the activation of 1200014M14Rik, resulting in its functional inhibition. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
This chemical is an inhibitor of c-Jun N-terminal kinase (JNK), and by inhibiting JNK, SP600125 can disrupt the signaling pathways that contribute to the functional activity of 1200014M14Rik, thereby inhibiting the protein. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Go6983 is a pan-PKC inhibitor that can disrupt PKC-mediated signaling pathways. Since PKC isoforms are involved in the functional regulation of 1200014M14Rik, its inhibition can lead to the suppression of 1200014M14Rik's activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
This chemical is a selective inhibitor of the Rho-associated protein kinase (ROCK). Inhibition of ROCK by Y-27632 can lead to changes in actin cytoskeleton dynamics, thereby inhibiting cellular processes involving 1200014M14Rik. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an inhibitor of Src family kinases. By inhibiting these kinases, PP2 can prevent the phosphorylation of 1200014M14Rik, thereby inhibiting its activity. | ||||||