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Tyrosinase 抗体 (6A207): sc-73244

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说明书
  • Tyrosinase抗体(6A207)是小鼠单克隆IgG2a κ, 在5篇文献中引用,规格为200 µg/ml
  • 免疫human物种的重组Tyrosinase
  • 推荐用于 mouse, rat 和 human 来源的Tyrosinase WB, IP, IF 和 IHC(P)检测
  • 看 Tyrosinase (T311): sc-20035,可查看有标记的 Tyrosinase 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和 2a BP-HRP">m-IgG2a BP-HRP是Tyrosinase Antibody (6A207) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。这些试剂现与Tyrosinase Antibody (6A207) 打包提供(请参阅下面的订购信息)。
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関連項目

酪氨酸酶(TYR)是一种I型膜蛋白和含铜酶,参与黑色素的生产,黑色素是脊椎动物中发现的主要色素。黑色素生物合成需要TYR的酶活性,它催化黑色素生物合成中酪氨酸羟化的关键和限速步骤。影响TYR活性的缺陷导致各种形式的白化病。与TYR相关的蛋白质TRP1和TRP2也在黑素细胞中特异性表达,它们同样有助于黑色素小体中黑色素的合成。包括TYR在内的TRPs都有一个类似的跨膜区,含有两个金属结合区和富含半胱氨酸的表皮生长因子基序,并定位于黑色素小体膜上。然而,这些蛋白质具有不同的催化活性,它们分别有助于黑色素生物聚合物的生物合成。据信,TRPs是以多酶复合物的形式存在的,因为这些蛋白质会聚集在一起形成聚集体,TRP1的表达也有助于稳定黑素细胞中的TYR。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Tyrosinase 抗体 (6A207) 参考文献:

  1. 酪氨酸酶催化氟苯酚的氧化。  |  Battaini, G., et al. 2002. J Biol Chem. 277: 44606-12. PMID: 12235154
  2. 眼皮肤白化病中酪氨酸酶基因的突变。  |  Shibahara, S. 1992. Pigment Cell Res. 5: 279-83. PMID: 1292010
  3. 酪氨酸酶同工酶的性质。  |  Tsukamoto, K., et al. 1992. Pigment Cell Res. Suppl 2: 84-9. PMID: 1409443
  4. 苯甲酸对酪氨酸酶的抑制动力学。  |  Kubo, I., et al. 2003. Z Naturforsch C J Biosci. 58: 713-8. PMID: 14577637
  5. 小鼠黑色素瘤中酪氨酸酶的失活机制。  |  Tomita, Y. and Seiji, M. 1977. J Dermatol. 4: 245-9. PMID: 15461355
  6. 固定在疏水膜上的酪氨酸酶。  |  Algieri, C., et al. 2017. Biotechnol Appl Biochem. 64: 92-99. PMID: 26607971
  7. 酪氨酸酶对间苯二酚的作用的表征。  |  Garcia-Jimenez, A., et al. 2016. Bioorg Med Chem. 24: 4434-4443. PMID: 27480027
  8. 杜松果实中的酪氨酸酶抑制类黄酮。  |  Jegal, J., et al. 2016. Biosci Biotechnol Biochem. 80: 2311-2317. PMID: 27492585
  9. 硫嘌呤类药物重新定位为酪氨酸酶抑制剂。  |  Choi, J., et al. 2017. Int J Mol Sci. 19: PMID: 29283382
  10. 生物质多酚作为潜在的酪氨酸酶抑制剂的估值。  |  Pham, TN., et al. 2024. Drug Discov Today. 29: 103843. PMID: 38000718

订购信息

产品名称产品编号规格价格数量收藏夹

Tyrosinase 抗体 (6A207)

sc-73244
200 µg/ml
$322.00

Tyrosinase (6A207): m-IgG Fc BP-HRP 套装

sc-539465
200 µg Ab; 10 µg BP
$361.00

Tyrosinase (6A207): m-IgG2a BP-HRP 套装

sc-546710
200 µg Ab; 10 µg BP
$361.00

Why can sc-73243 and sc-73244 show teh same data? These are the same antibody?

Asked by: taro27
Thank you for your question. Yes, these are the same antibody. This antibody is recognized by alternative clone designations in the literature, and so we offer the same antibody under the separate clone names.
Answered by: Technical Support
Date published: 2019-07-18

Can Tyrosinase (6A207): sc-73244 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: jenniferc
Thank you for your question. Yes, Tyrosinase (6A207): sc-73244 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-01
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Rated 4 out of 5 by CJ from Strong band in WB in human Tyrosinase transfectedStrong band in WB in human Tyrosinase transfected 293T and A-375 whole cell lysates. -SCBT QC
Date published: 2013-01-18
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Tyrosinase 抗体 (6A207) is rated 4.0 out of 5 by 1.
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