Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
PC-PLD2 Antibody (B-3) is a high quality monoclonal PC-PLD2 antibody (also designated Phospholipase D2 antibody, Choline Phosphatase 2 antibody, Phosphatidylcholine-Hydrolyzing Phospholipase D2 antibody, PLD1C antibody, PLD 2 antibody, or HPLD2 antibody) suitable for the detection of the PC-PLD2 protein of mouse, rat and human origin. PC-PLD2 Antibody (B-3) is available as both the non-conjugated anti-PC-PLD2 antibody form, as well as multiple conjugated forms of anti-PC-PLD2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Virtually every cell uses phosphatidylcholine as a substrate to produce phosphatidic acid and choline. Phosphatidylcholine phospholipase D1 and D2 (PC-PLD1 and PC-PLD2) are phospholipid-specific phosphodiesterases that hydrolyze phosphatidylcholine. Unlike PC-PLD1, which associates with secretory granules, PC-PLD2 localizes to the plasma membrane, where it is implicated in the formation of endocytotic vesicles. Both PC-PLD1 and PC-PLD2 coordinately regulate macrophage phagocytosis. PC-PLD activity in mammalian cells is transiently stimulated upon activation by G protein-coupled and receptor tyrosine kinase cell surface receptors. For example, PC-PLD1 and PC-PLD2 participate in sphingosine 1-phosphate stimulation of ERK phosphorylation and IL-8 secretion in bronchial epithelial cells. In addition, tubulin binding to PC-PLD2 inhibits muscarinic receptor-linked PC-PLD2 activation. PC-PLD2 also enhances PKCzeta activity through direct interaction in a lipase activity-independent manner. PC-PLD1 and PC-PLD2 stimulate cell growth by repressing expression of p21 gene through p53-dependent and p53-independent pathways, respectively, which may ultimately lead to carcinogenesis.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
I need to use an antibody to detect the protein in samples of porcine origin. Do you know if PC-PLD2 (B-3): sc-515744 mouse monoclonal antibody will work?
Asked by: Randy McDonald
Thank you for your inquiry. Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity. We are available by phone, e-mail or chat.