PC-PLD2 Activators
PC-PLD2, also known as Phosphatidylcholine-specific phospholipase D2, is an enzyme involved in cellular signaling and membrane trafficking processes. It catalyzes the hydrolysis of phosphatidylcholine (PC) to generate the signaling lipid phosphatidic acid (PA) and choline. PC-PLD2 is ubiquitously expressed in various tissues and cell types, where it plays crucial roles in diverse cellular functions such as cell growth, proliferation, migration, and vesicular trafficking. Specifically, PC-PLD2 is implicated in regulating intracellular vesicle trafficking pathways, including endocytosis, exocytosis, and vesicle fusion events, thereby influencing membrane dynamics and cellular signaling.
Activation of PC-PLD2 is mediated through multiple signaling pathways and mechanisms. One prominent activation mechanism involves the regulation of its enzymatic activity by small GTPases, such as ADP-ribosylation factor (ARF) and Rho family GTPases. Activation of these GTPases leads to the recruitment of PC-PLD2 to specific membrane compartments, where it catalyzes the production of phosphatidic acid, consequently modulating downstream signaling events. Additionally, PC-PLD2 can be activated by various stimuli, including growth factors, hormones, neurotransmitters, and cellular stressors, through receptor-mediated signaling pathways. These stimuli trigger intracellular signaling cascades that converge on PC-PLD2, either directly or indirectly, leading to its activation and subsequent generation of phosphatidic acid. Understanding the intricate mechanisms governing PC-PLD2 activation is essential for elucidating its physiological functions and regulatory roles in cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic Acid can directly activate PC-PLD2 by serving as a substrate for the enzyme, promoting phospholipid hydrolysis and the generation of phosphatidic acid, leading to PC-PLD2 activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA can activate PC-PLD2 by stimulating Protein Kinase C (PKC), which phosphorylates and activates PC-PLD2 through downstream signaling cascades initiated by PKC activation. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
LPA activates G-protein-coupled receptors, leading to the activation of PC-PLD2 through downstream signaling pathways, such as the Rho GTPase pathway, ultimately promoting PC-PLD2 activity. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
LPS can indirectly activate PC-PLD2 by stimulating the NF-κB pathway, which can influence PC-PLD2 expression and activity through transcriptional regulation, contributing to its activation. | ||||||
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $51.00 $100.00 $310.00 $690.00 | 3 | |
Angiotensin II activates angiotensin receptors, triggering signaling pathways that can indirectly activate PC-PLD2 through second messenger systems, such as inositol trisphosphate (IP3) signaling. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates insulin receptors, leading to PC-PLD2 activation through the insulin signaling pathway, which includes PI3K activation and subsequent modulation of PC-PLD2 activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P activates S1P receptors, triggering signaling pathways that can indirectly activate PC-PLD2 through second messenger systems, such as calcium mobilization and downstream effectors. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
GPCR agonists activate G-protein-coupled receptors (GPCRs), which can lead to PC-PLD2 activation through downstream signaling pathways initiated by GPCR activation and intracellular calcium release. | ||||||
Bradykinin | 58-82-2 | sc-507311 | 5 mg | $110.00 | ||
Bradykinin activates its receptor, initiating signaling cascades that can indirectly activate PC-PLD2 through the Gq/11-protein-coupled receptor pathway, ultimately enhancing PC-PLD2 activity. | ||||||
Vasopressin | 11000-17-2 | sc-356188 sc-356188A | 5 mg 25 mg | $260.00 $1040.00 | 1 | |
Vasopressin activates its receptor, leading to PC-PLD2 activation through G-protein-coupled receptor signaling pathways, including phospholipase C activation and calcium mobilization. | ||||||