Date published: 2025-9-7
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LOX Antibody (F-8) - Western Blotting - Image 306202
LOX 抗体 (F-8): sc-373995. WI-38 (A) 和 MCF7 (B) 全细胞裂解液中 LOX 表达的 Western 印迹分析.
LOX 抗体 (F-8): sc-373995. WI-38 (A) 和 MCF7 (B) 全细胞裂解液中 LOX 表达的 Western 印迹分析.

LOX 抗体 (F-8): sc-373995

4.8(8)
寫評論提問

说明书
  • LOX抗体(F-8)是小鼠单克隆IgG2a κ, 在17篇文献中引用，规格为200 µg/ml
  • 特异性抗原位于human物种的LOX的内部区域内的氨基酸160-193之间
  • 抗-LOX 抗体 (F-8) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA，检测mouse, rat 和human 来源的 Lysyl oxidase (LOX); 也和以下物种反应，包括： 和 canine and porcine
  • 抗LOX抗体（F-8）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取LOX (F-8): sc-373995的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG2a BP-HRP 和 m-IgGκ BP-HRP 是 LOX 抗体 (F-8) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与LOX 抗体 (F-8) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

LOX 抗体（F-8）是一种 IgG2a κ 小鼠单克隆 LOX 抗体（也称为 LOX 抗体或赖氨酰氧化酶抗体），可通过 WB、IP、IF、IHC(P) 和 ELISA 检测到小鼠、大鼠和人类的赖氨酰氧化酶（LOX）。LOX 抗体（F-8）既可以是非偶联的抗 LOX 抗体形式，也可以是多种偶联形式的抗 LOX 抗体，包括琼脂糖、HRP、PE、FITC 和多种 Alexa Fluor® 偶联物。细胞外蛋白的赖氨酰氧化酶家族包括 LOX 和四种类 LOX 酶，它们负责胶原和弹性蛋白的肽基赖氨酸残基的去氨基作用。它们还催化分子间和分子内的交联反应。LOX 的过度表达可能由于其对降解酶的高抗性而导致严重的纤维化退变。前胶原 C 蛋白酶活性将 LOX 从前体蛋白加工为成熟形式。LOX 的激活发生在正常发育和成人皮肤中，LOX 表达和活性的改变与皮肤衰老和衰老相关。LOX 对于心血管和呼吸系统的发育至关重要。此外，LOX 在癌症、伤口愈合以及细胞运动、趋化和分化中发挥作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

LOX 抗体 (F-8) 参考文献:

  1. 多种与骨形态发生蛋白 1 相关的哺乳动物金属蛋白酶在正确的生理部位处理原赖氨酰氧化酶，并控制小鼠胚胎成纤维细胞培养物中赖氨酰氧化酶的活化。  |  Uzel, MI., et al. 2001. J Biol Chem. 276: 22537-43. PMID: 11313359
  2. 赖氨酰氧化酶的前肽结构域可诱导ras转化细胞的表型逆转。  |  Palamakumbura, AH., et al. 2004. J Biol Chem. 279: 40593-600. PMID: 15277520
  3. 用香烟烟雾冷凝物处理的大鼠胎肺成纤维细胞中赖氨酸氧化酶的下调和细胞硫醇的上调。  |  Chen, LJ., et al. 2005. Toxicol Sci. 83: 372-9. PMID: 15509664
  4. 细胞纤连蛋白能与溶酶体氧化酶高亲和力结合，对其蛋白水解活化至关重要。  |  Fogelgren, B., et al. 2005. J Biol Chem. 280: 24690-7. PMID: 15843371
  5. 赖氨酰氧化酶在皮肤发育, 老化和病变中的作用。  |  Szauter, KM., et al. 2005. Pathol Biol (Paris). 53: 448-56. PMID: 16085123
  6. 遗传性肾病小鼠肾脏慢性肾脏纤维化中由转化生长因子-β1介导的赖氨酰氧化酶上调。  |  Goto, Y., et al. 2005. Virchows Arch. 447: 859-68. PMID: 16086153
  7. 赖氨酰氧化酶对呼吸系统的正常发育和功能以及各种组织中弹性纤维和胶原纤维的完整性至关重要。  |  Mäki, JM., et al. 2005. Am J Pathol. 167: 927-36. PMID: 16192629
  8. 肺纤维化中的 LOX/LOXL：潜在的治疗目标。  |  Chen, L., et al. 2019. J Drug Target. 27: 790-796. PMID: 30457362
  9. 靶向赖氨酰氧化酶（LOX）可克服三阴性乳腺癌的化疗耐药性。  |  Saatci, O., et al. 2020. Nat Commun. 11: 2416. PMID: 32415208
  10. LOX 可防止腹主动脉瘤破裂。  |  Mogi, M. 2023. Hypertens Res. 46: 801-802. PMID: 36635531
  11. 单细胞分析揭示了参与糖尿病小鼠心脏纤维化的赖氨酰氧化酶（Lox）+成纤维细胞亚群。  |  Li, H., et al. 2023. J Adv Res. 54: 223-237. PMID: 36706988
  12. 赖氨酰氧化酶（LOX(L)）在病理钙化中的作用  |  Faure, E., et al. 2024. Biomed Pharmacother. 181: 117719. PMID: 39603039

订购信息

产品名称产品编号规格价格数量收藏夹

LOX 抗体 (F-8)

sc-373995
200 µg/ml
$316.00

LOX (F-8): m-IgG Fc BP-HRP 套装

sc-529631
200 µg Ab; 10 µg BP
$354.00

LOX (F-8): m-IgGκ BP-HRP 套装

sc-522584
200 µg Ab, 40 µg BP
$354.00

LOX (F-8): m-IgG2a BP-HRP 套装

sc-547347
200 µg Ab; 10 µg BP
$354.00

LOX 抗体 (F-8) AC

sc-373995 AC
500 µg/ml, 25% agarose
$416.00

LOX 抗体 (F-8) HRP

sc-373995 HRP
200 µg/ml
$316.00

LOX 抗体 (F-8) FITC

sc-373995 FITC
200 µg/ml
$330.00

LOX 抗体 (F-8) PE

sc-373995 PE
200 µg/ml
$343.00

LOX 抗体 (F-8) Alexa Fluor® 488

sc-373995 AF488
200 µg/ml
$357.00

LOX 抗体 (F-8) Alexa Fluor® 546

sc-373995 AF546
200 µg/ml
$357.00

LOX 抗体 (F-8) Alexa Fluor® 594

sc-373995 AF594
200 µg/ml
$357.00

LOX 抗体 (F-8) Alexa Fluor® 647

sc-373995 AF647
200 µg/ml
$357.00

LOX 抗体 (F-8) Alexa Fluor® 680

sc-373995 AF680
200 µg/ml
$357.00

LOX 抗体 (F-8) Alexa Fluor® 790

sc-373995 AF790
200 µg/ml
$357.00

LOX (F-8) 中和勝肽

sc-373995 P
100 µg/0.5 ml
$68.00

I would like to know what is the negative control for LOX and LMO2 antibody? its preety urgent. I am awaiting to hear from you in your best conveniuence!!

Asked by: Mahmud
Thank you for your question. We do not have a negative control peptide for this antibody, but we would suggest using a normal mouse IgG2a (https://www.scbt.com/p/normal-mouse-igg2a) as a negative control for this LOX antibody. You can find the appropriate normal mouse IgG for your LMO2 antibody here: https://www.scbt.com/browse/Control-IgGs-and-IgG-Conjugates/_/N-1j3ajah
Answered by: Tech Service
Date published: 2020-02-13

Can the LOX (F-8): sc-373995 mouse monoclonal antibody be used for immunohistochemical staining of mouse tissue?

Asked by: cjMara
Yes. For the best results, we recommend using either a directly conjugated monoclonal antibody, or our highly specific mouse IgG binding protein conjugated to HRP (sc-516102). This primary antibody is available directly conjugated to HRP, PE, FITC, Alexa Fluor® 488, or Alexa Fluor® 647.
Answered by: Technical Support 15
Date published: 2017-01-22
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Rated 4 out of 5 by from Good resultsI try LOX antibody one month ago, good results in prostate cancer model
Date published: 2025-07-08
Rated 5 out of 5 by from ottimo anticorpoAbbiamo acquistato l'anticorpo per analisi WB, nessun problema da segnalare, ottimo prodotto. Consigliato
Date published: 2022-03-28
Rated 4 out of 5 by from Work well in WB analysisThis antibody works well in western blot analysis of mouse liver lysate
Date published: 2017-10-02
Rated 4 out of 5 by from Good antibodyI used this antibody in liver cell line. The major band located in 50KD.
Date published: 2017-08-21
Rated 5 out of 5 by from both extracellular and nuclear lox can be detectedIn our hands, this antibody detect extra cellular Lox well and nuclear Lox either.
Date published: 2017-02-13
Rated 5 out of 5 by from OutstandingGreat product for western blot, IF and IHC staining applications
Date published: 2017-02-05
Rated 5 out of 5 by from Wise choice in antibody...This LOX antibody will not disappoint! Strong for WB and IF, but also specific and reliable for IHC.
Date published: 2017-01-09
Rated 5 out of 5 by from Great bands seen in WB using WIGreat bands seen in WB using WI-38 and MCF7 whole cell lysates. -SCBT QC
Date published: 2015-05-16
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LOX 抗体 (F-8) is rated 4.7 out of 5 by 9.
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