GRK 2 Antibody (G-12): sc-271359
- GRK 2 Antibody (G-12) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 661-699 near the C-terminus of GRK 2 of human origin
- recommended for detection of GRK 2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and bovine, porcine and canine
- See GRK 2 (C-9): sc-13143 for GRK 2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GRK 2 Antibody (G-12) for WB and IHC(P) applications. These reagents are now offered in bundles with GRK 2 Antibody (G-12) (see ordering information below).
GRK 2 Antibody (G-12) is a mouse monoclonal IgG2a antibody that detects GRK 2 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). GRK 2, a member of the G protein-coupled receptor kinase family, plays a crucial role in the regulation of G protein-coupled receptor signaling by phosphorylating activated receptors, which leads to their desensitization and internalization. This process is vital for maintaining cellular responsiveness to external signals, as GRK 2 prevents overstimulation and allows for the fine-tuning of physiological responses. GRK 2 (G-12) monoclonal antibody enables researchers to study receptor activity modulation in various physiological processes, including cardiovascular function and neurotransmission, making GRK 2 a significant target for research into diseases related to dysregulated signaling pathways. Anti-GRK 2 antibody (G-12) provides a reliable tool for studying the dynamics of G protein signaling and the role of GRK 2 in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GRK 2 Antibody (G-12) References:
- GRK2-dependent desensitization downstream of G proteins. | Jurado-Pueyo, M., et al. 2008. J Recept Signal Transduct Res. 28: 59-70. PMID: 18437630
- G protein-coupled receptor kinase 2 (GRK2) in migration and inflammation. | Penela, P., et al. 2008. Arch Physiol Biochem. 114: 195-200. PMID: 18618354
- Sustained GRK2-dependent CREB activation is essential for α2-adrenergic receptor-induced PC12 neuronal differentiation. | Karkoulias, G., et al. 2020. Cell Signal. 66: 109446. PMID: 31678682
- The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions. | Sorriento, D., et al. 2021. Cells. 10: PMID: 33467677
- Targeting GRK2 and GRK5 for treating chronic degenerative diseases: Advances and future perspectives. | Zhang, Y., et al. 2022. Eur J Med Chem. 243: 114668. PMID: 36055000
- Paeoniflorin-6'-O-benzene sulfonate protected the intestinal epithelial barrier by restoring the inhibitory effect of GRK2 and β-arrestin 2 on ERK1/2-NF-κB. | Jiang, M., et al. 2023. Phytother Res. 37: 743-758. PMID: 36223242
- A novel GRK2 inhibitor alleviates experimental arthritis through restraining Th17 cell differentiation. | Tao, J., et al. 2023. Biomed Pharmacother. 157: 113997. PMID: 36399825
- Cardioprotective Effects of the GRK2 Inhibitor Paroxetine on Isoproterenol-Induced Cardiac Remodeling by Modulating NF-κB Mediated Prohypertrophic and Profibrotic Gene Expression. | Alonazi, AS., et al. 2023. Int J Mol Sci. 24: PMID: 38139099
- Hepatic GRK2 is dispensable for glucose homeostasis and other key metabolic parameters in mice. | Oteng, AB., et al. 2024. Mol Metab. 79: 101866. PMID: 38159884
- Paroxetine alleviates dendritic cell and T lymphocyte activation via GRK2-mediated PI3K-AKT signaling in rheumatoid arthritis. | Liu, T., et al. 2024. Chin Med J (Engl).. PMID: 38879805
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GRK 2 Antibody (G-12) | sc-271359 | 200 µg/ml | $322.00 | |||
GRK 2 Antibody (G-12): m-IgG Fc BP-HRP Bundle | sc-537623 | 200 µg Ab; 10 µg BP | $361.00 | |||
GRK 2 Antibody (G-12): m-IgGκ BP-HRP Bundle | sc-534941 | 200 µg Ab; 40 µg BP | $361.00 | |||
GRK 2 Antibody (G-12): m-IgG2a BP-HRP Bundle | sc-548070 | 200 µg Ab; 10 µg BP | $361.00 | |||
GRK 2 (G-12) Neutralizing Peptide | sc-271359 P | 100 µg/0.5 ml | $69.00 |