CD71/TFRC/Transferrin Receptor Antibody (Ber-T9): sc-19675

CD71 Antibody (Ber-T9) is a mouse monoclonal IgG1 antibody that detects CD71 in human samples through immunofluorescence (IF) and flow cytometry (FCM) applications. CD71, also known as the transferrin receptor (TFR), is a type II membrane glycoprotein that plays a crucial role in iron homeostasis by facilitating cellular uptake of iron through receptor-mediated endocytosis. This protein exists as a disulfide-linked homodimer, composed of two identical subunits, and binds to transferrin, a serum iron-transport protein, allowing cells to acquire iron necessary for various biological processes, including hemoglobin synthesis and cellular respiration. CD71 is typically expressed at high levels on proliferating cells, reticulocytes, and erythroid precursors, while CD71 expression is upregulated in activated lymphocytes, monocytes, and macrophages, making CD71 a valuable marker for studying cell proliferation and activation. Additionally, CD71 is present on most dividing cells and brain endothelium, highlighting CD71′s importance in both hematopoiesis and neurobiology. CD71′s presence on these cell types underscores CD71′s significance in iron metabolism and potential implications in disorders related to iron overload, such as hereditary hemochromatosis type III, which is associated with mutations in the TFR2 gene. Anti-CD71 antibody (Ber-T9) is an essential tool for researchers investigating iron transport mechanisms and related pathologies.

The preferred CD71/TFRC/Transferrin Receptor antibody is CD71/TFRC/Transferrin Receptor Antibody (3B8 2A1): sc-32272.