Date published: 2026-7-15

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IRAK Antibodies

Santa Cruz Biotechnology supplies a comprehensive collection of IRAK Antibodies for research focused on interleukin-1 receptor-associated kinase (IRAK) in cellular processes. IRAK Antibodies are validated for western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). IRAK proteins function as essential mediators in signaling pathways of the immune response, particularly in Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling. The activation of downstream signaling cascades leads to pro-inflammatory cytokine production, influencing both innate and adaptive immunity. IRAK signaling research continues to reveal new insights about immune regulation and potential therapeutic targets in inflammatory diseases. Investigating IRAK proteins has become increasingly important for understanding autoimmune disorders and developing targeted treatments. Current research focuses on mapping IRAK signaling networks and their impact on cellular responses. Understanding IRAK function helps advance knowledge of immune system regulation and inflammatory disease mechanisms. Santa Cruz Biotechnology monoclonal antibodies support researchers worldwide in advancing scientific understanding of IRAK proteins and their role in human health.

SEE ALSO...

IRAK Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

IRAK-1 Antibody (F-4)

sc-5288mouse IgG1 κ440-712 (h)WB, IP, IF, IHC(P), ELISAm, r, h
79
(14)

IRAK-1 Antibody (C-2)

sc-5287mouse IgG2a κ440-712 (h)WB, IP, IF, IHC(P), ELISAh
8
(6)

IRAK-1 Antibody (B-5)

sc-55530mouse IgG2b κ440-712 (h)WB, IP, IF, ELISAh
6
(6)

IRAK-1 Antibody (B-8)

sc-515499mouse IgG2a692-712 (h)WB, IP, IF, ELISAh

new

(2)

IRAK-1 Antibody (E-5)

sc-515512mouse IgG1689-712 (h)WB, IP, IF, ELISAm, r, h
1
(2)

IRAK-2 Antibody (D-8)

sc-515885mouse IgG2b κ1-112 (h)WB, IP, IF, IHC(P), ELISAh

new

(1)

IRAK-4 Antibody (G-2)

sc-374349mouse IgG2a κ1-100 (h)WB, IP, IF, IHC(P), ELISAh
3
(9)

IRAK-4 Antibody (5-RY38)

sc-134368mouse IgG1 κ1-130 (h)WB, IP, ELISAh
1
(1)

IRAK-M Antibody (XX-6)

sc-100389mouse IgG1 κ497-596 (h)WB, IP, ELISAh
2
(4)

IRAK siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

IRAK-M siRNA (h)

sc-39098hGene SilencingN/A
3
(1)

IRAK-M shRNA Plasmid (h)

sc-39098-SHhGene SilencingPuromycin
3
(1)

IRAK-M shRNA (h) Lentiviral Particles

sc-39098-VhGene SilencingPuromycin
3
(1)

IRAK-M siRNA (m)

sc-146282mGene SilencingN/A
4
(0)

IRAK-M shRNA Plasmid (m)

sc-146282-SHmGene SilencingPuromycin
4
(0)

IRAK-M shRNA (m) Lentiviral Particles

sc-146282-VmGene SilencingPuromycin
4
(0)

IRAK-1 siRNA (h)

sc-35704hGene SilencingN/A
7
(0)

IRAK-1 shRNA Plasmid (h)

sc-35704-SHhGene SilencingPuromycin
7
(0)

IRAK-1 shRNA (h) Lentiviral Particles

sc-35704-VhGene SilencingPuromycin
7
(0)

IRAK-1 siRNA (m)

sc-35705mGene SilencingN/A
6
(0)

IRAK-1 shRNA Plasmid (m)

sc-35705-SHmGene SilencingPuromycin
6
(0)

IRAK-1 shRNA (m) Lentiviral Particles

sc-35705-VmGene SilencingPuromycin
6
(0)

IRAK-1 siRNA (r)

sc-270326rGene SilencingN/A
1
(0)

IRAK-1 shRNA Plasmid (r)

sc-270326-SHrGene SilencingPuromycin
1
(0)

IRAK-1 shRNA (r) Lentiviral Particles

sc-270326-VrGene SilencingPuromycin
1
(0)

IRAK-2 siRNA (h)

sc-106916hGene SilencingN/A0
(0)

IRAK-2 shRNA Plasmid (h)

sc-106916-SHhGene SilencingPuromycin0
(0)

IRAK-2 shRNA (h) Lentiviral Particles

sc-106916-VhGene SilencingPuromycin0
(0)

IRAK-2 siRNA (m)

sc-146281mGene SilencingN/A
2
(0)

IRAK-2 shRNA Plasmid (m)

sc-146281-SHmGene SilencingPuromycin
2
(0)

IRAK-2 shRNA (m) Lentiviral Particles

sc-146281-VmGene SilencingPuromycin
2
(0)

IRAK-4 siRNA (h)

sc-45400hGene SilencingN/A
1
(0)

IRAK-4 shRNA Plasmid (h)

sc-45400-SHhGene SilencingPuromycin
1
(0)

IRAK-4 shRNA (h) Lentiviral Particles

sc-45400-VhGene SilencingPuromycin
1
(0)

IRAK-4 siRNA (m)

sc-45401mGene SilencingN/A
3
(0)

IRAK-4 shRNA Plasmid (m)

sc-45401-SHmGene SilencingPuromycin
3
(0)

IRAK-4 shRNA (m) Lentiviral Particles

sc-45401-VmGene SilencingPuromycin
3
(0)

IRAK CRISPR Knockout (KO) and HDR Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

IRAK-M CRISPR/Cas9 KO Plasmid (h2)

sc-403219-KO-2Gene Knockouth0
(0)

IRAK-M HDR Plasmid (h2)

sc-403219-HDR-2Homology Directed Repairh0
(0)

IRAK-M CRISPR/Cas9 KO Plasmid (m2)

sc-428667-KO-2Gene Knockoutm0
(0)

IRAK-1 CRISPR/Cas9 KO Plasmid (h)

sc-400264Gene Knockouth0
(0)

IRAK-1 HDR Plasmid (h)

sc-400264-HDRHomology Directed Repairh0
(0)

IRAK-1 CRISPR/Cas9 KO Plasmid (m)

sc-421100Gene Knockoutm0
(0)

IRAK-2 CRISPR/Cas9 KO Plasmid (h)

sc-404304Gene Knockouth0
(0)

IRAK-2 HDR Plasmid (h)

sc-404304-HDRHomology Directed Repairh0
(0)

IRAK-4 CRISPR/Cas9 KO Plasmid (h)

sc-416405Gene Knockouth0
(0)

IRAK-4 HDR Plasmid (h)

sc-416405-HDRHomology Directed Repairh0
(0)

IRAK CRISPR Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

IRAK-M Double Nickase Plasmid (h)

sc-403219-NICGene Knockouth0
(0)

IRAK-M Double Nickase Plasmid (h2)

sc-403219-NIC-2Gene Knockouth0
(0)

IRAK-1 Double Nickase Plasmid (h)

sc-400264-NICGene Knockouth0
(0)

IRAK-1 Double Nickase Plasmid (h2)

sc-400264-NIC-2Gene Knockouth0
(0)

IRAK-2 Double Nickase Plasmid (h)

sc-404304-NICGene Knockouth0
(0)

IRAK-2 Double Nickase Plasmid (h2)

sc-404304-NIC-2Gene Knockouth0
(0)

IRAK-4 Double Nickase Plasmid (m)

sc-435222-NICGene Knockoutm0
(0)

IRAK-4 Double Nickase Plasmid (m2)

sc-435222-NIC-2Gene Knockoutm0
(0)

IRAK CRISPR Activation Plasmids and Lentiviral Particles

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

IRAK-M CRISPR Activation Plasmid (h)

sc-403219-ACTGene Activationh0
(0)

IRAK-M CRISPR Activation Plasmid (h2)

sc-403219-ACT-2Gene Activationh0
(0)

IRAK-1 CRISPR Activation Plasmid (h)

sc-400264-ACTGene Activationh0
(0)

IRAK-1 CRISPR Activation Plasmid (h2)

sc-400264-ACT-2Gene Activationh0
(0)

IRAK-1 CRISPR Activation Plasmid (m)

sc-421100-ACTGene Activationm0
(0)

IRAK-2 CRISPR Activation Plasmid (h)

sc-404304-ACTGene Activationh0
(0)

IRAK-4 CRISPR Activation Plasmid (h)

sc-416405-ACTGene Activationh0
(0)

IRAK-4 CRISPR Activation Plasmid (h2)

sc-416405-ACT-2Gene Activationh0
(0)