CFTR Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Glyburide (Glibenclamide) | 10238-21-8 | sc-200982 sc-200982A sc-200982D sc-200982B sc-200982C | 1 g 5 g 25 g 100 g 500 g | $46.00 $61.00 $117.00 $173.00 $530.00 | 36 | |
Glyburide, a sulfonylurea derivative, demonstrates intriguing interactions with the CFTR channel, particularly in modulating its conductance. Its specific binding affinity to the channel's nucleotide-binding domains can alter conformational states, influencing chloride ion flow. The compound's hydrophobic regions promote membrane integration, while its polar functionalities enhance solubility in biological systems. This duality allows for nuanced effects on cellular ion homeostasis and transport kinetics. | ||||||
CFTR Inhibitor-172 | 307510-92-5 | sc-204680 sc-204680A | 10 mg 50 mg | $168.00 $520.00 | 10 | |
CFTR Inhibitor-172 is a selective compound that interacts with the CFTR protein, specifically targeting its regulatory domains. This inhibitor disrupts the channel's gating mechanisms, leading to altered ion transport dynamics. Its unique structure facilitates specific hydrogen bonding and hydrophobic interactions, which can stabilize certain conformations of the CFTR protein. The compound's kinetic profile suggests a rapid onset of action, influencing chloride ion permeability and cellular ion balance. | ||||||
Ivacaftor | 873054-44-5 | sc-364679 | 5 mg | $259.00 | ||
Ivacaftor is a CFTR potentiator that enhances chloride channel activity by binding to the CFTR protein and improving its function at the cell surface. | ||||||
PPQ-102 | 931706-15-9 | sc-364673 | 10 mg | $298.00 | 1 | |
PPQ-102 is a potent modulator of the CFTR protein, exhibiting unique binding characteristics that enhance its interaction with the channel's nucleotide-binding domains. This compound promotes conformational changes that affect channel opening and closing, thereby influencing ion flow. Its distinct molecular architecture allows for specific electrostatic interactions, which can stabilize intermediate states of CFTR. The reaction kinetics indicate a gradual yet sustained effect on ion transport, contributing to altered cellular homeostasis. | ||||||
CFTR Inhibitor II, GlyH-101 | 328541-79-3 | sc-221418 | 5 mg | $270.00 | 7 | |
CFTR Inhibitor II, GlyH-101 is a selective inhibitor of the CFTR chloride channel, characterized by its ability to disrupt ion transport through specific allosteric modulation. This compound engages in unique hydrophobic interactions with the transmembrane domains, leading to altered channel dynamics. Its kinetic profile reveals a rapid onset of action, with a notable impact on the gating mechanisms of CFTR, ultimately affecting cellular ion balance and signaling pathways. | ||||||