CFTR Inhibitor II, GlyH-101 CAS: 328541-79-3
MF: C19H15Br2N3O3
MW: 493.15
CFTR Inhibitor II, GlyH-101 is a CFTR inhibitor.

CFTR Inhibitor II, GlyH-101 (CAS 328541-79-3)

CFTR Inhibitor II, GlyH-101 | CAS 328541-79-3 is rated 5.0 out of 5 by 1.
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Alternate Names: N-(2-Naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide
Application: CFTR Inhibitor II, GlyH-101 is a CFTR inhibitor
CAS Number: 328541-79-3
Purity: ≥97%
Molecular Weight: 493.15
Molecular Formula: C19H15Br2N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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CFTR Inhibitor II, GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR.


References

1. Laverty, G. et al. 2012. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 161(1): 53-60. PMID: 21964154
> 15277574, 16317066, 21964154 1. Muanprasat, C. et al. 2004. J. Gen. Physiol. 124(2): 125-137. PMID: 15277574
2. Sonawane, N.D. et al. 2006. FASEB J. 20(1): 130-132. PMID: 16317066
3. Laverty, G. et al. 2012. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 161(1): 53-60. PMID: 21964154

Physical State :
Solid
Solubility :
Soluble in DMSO (200 mg/ml).
Storage :
Store at 4° C
Melting Point :
>300° C
Density :
1.7 g/cm3 (Predicted)
Refractive Index :
n20D 1.70 (Predicted)
IC50 :
Cystic fibrosis transmembrane conductance regulator: IC50 = 5 µM (human)
Ki Data :
Apical membrane Cl– current: Ki= 4.3 µM (CFTR-expressing FRT cells)
pK Values :
pKa: 5.99 (Predicted), pKb: 3.11 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD01532954
SMILES :
C1=CC=C2C=C(C=CC2=C1)NCC(=O)NN/C=C/3\\C=C(C(=C(C3=O)Br)O)Br

Download SDS (MSDS)

Certificate of Analysis

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CFTR Inhibitor II, GlyH-101 (CAS 328541-79-3)  Product Citations

See how others have used CFTR Inhibitor II, GlyH-101 (CAS 328541-79-3). Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 29351391  Mroz, MS.|Lajczak, NK.|Goggins, BJ.|Keely, S.|Keely, SJ.| et al. 2018. Am. J. Physiol. Gastrointest. Liver Physiol. 314: G378-G387.

PMID: # 28701694  Zhang, JT. et al. 2017. Sci Rep. 7: 5233.

PMID: # 28428011  Tarique, AA.|Sly, PD.|Holt, PG.|Bosco, A.|Ware, RS.|Logan, J.|Bell, SC.|Wainwright, CE.|Fantino, E.| et al. 2017. J. Cyst. Fibros. 16: 475-482.

PMID: # 28455748  Ibrahim, SH.|Turner, MJ.|Saint-Criq, V.|Garnett, J.|Haq, IJ.|Brodlie, M.|Ward, C.|Borgo, C.|Salvi, M.|Venerando, A.|Gray, MA.| et al. 2017. Pflugers Arch. 469: 1073-1091.

PMID: # 27827428  Fujii, S. et al. 2016. Sci Rep. 6: 36795.

PMID: # 25792563  Tang, L. et al. 2015. Am. J. Physiol. Gastrointest. Liver Physiol. 308: G874-83.

PMID: # 32306956  BMC Complement Med Ther. 20: 118.

Citations 1 to 7 of 7 total
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Rated 5 out of 5 by from Laverty Laverty, G. et al. (PubMed 21964154) used GlyH-101 (CFTR Inhibitor II) to conclude that avian renal proximal tubules utilize an apical CFTR Cl(-) channel to mediate cAMP-activated Cl(-) secretion. -SCBT Publication Review
Date published: 2015-03-31
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