Molecular structure of CFTR Inhibitor II, GlyH-101, CAS Number: 328541-79-3
CFTR Inhibitor II, GlyH-101 (CAS 328541-79-3)
See product citations (7)
Alternate Names:
N-(2-Naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide
Application:
CFTR Inhibitor II, GlyH-101 is a CFTR inhibitor
CAS Number:
328541-79-3
Purity:
≥97%
Molecular Weight:
493.15
Molecular Formula:
C19H15Br2N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CFTR Inhibitor II, GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR. CFTR Inhibitor II, GlyH-101 is a compound that selectively inhibits the cystic fibrosis transmembrane conductance regulator (CFTR) protein. CFTR is an ion channel involved in the regulation of chloride and bicarbonate transport across cell membranes. CFTR Inhibitor II, GlyH-101 specifically targets and blocks CFTR, leading to reduced chloride ion transport.
CFTR Inhibitor II, GlyH-101 (CAS 328541-79-3) References
- Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. | Muanprasat, C., et al. 2004. J Gen Physiol. 124: 125-37. PMID: 15277574
- Luminally active, nonabsorbable CFTR inhibitors as potential therapy to reduce intestinal fluid loss in cholera. | Sonawane, ND., et al. 2006. FASEB J. 20: 130-2. PMID: 16317066
- SLC26A9 is a constitutively active, CFTR-regulated anion conductance in human bronchial epithelia. | Bertrand, CA., et al. 2009. J Gen Physiol. 133: 421-38. PMID: 19289574
- Cystic fibrosis transmembrane regulator inhibitors CFTR(inh)-172 and GlyH-101 target mitochondrial functions, independently of chloride channel inhibition. | Kelly, M., et al. 2010. J Pharmacol Exp Ther. 333: 60-9. PMID: 20051483
- Cardiac ion channel current modulation by the CFTR inhibitor GlyH-101. | Barman, PP., et al. 2011. Biochem Biophys Res Commun. 408: 12-7. PMID: 21439936
- Divergent CFTR orthologs respond differently to the channel inhibitors CFTRinh-172, glibenclamide, and GlyH-101. | Stahl, M., et al. 2012. Am J Physiol Cell Physiol. 302: C67-76. PMID: 21940661
- CFTR mediated chloride secretion in the avian renal proximal tubule. | Laverty, G., et al. 2012. Comp Biochem Physiol A Mol Integr Physiol. 161: 53-60. PMID: 21964154
- CFTR channel pharmacology: insight from a flock of clones. Focus on 'Divergent CFTR orthologs respond differently to the channel inhibitors CFTRinh-172, glibenclamide, and GlyH-101'. | Sheppard, DN. 2012. Am J Physiol Cell Physiol. 302: C24-6. PMID: 21998142
- Locating a plausible binding site for an open-channel blocker, GlyH-101, in the pore of the cystic fibrosis transmembrane conductance regulator. | Norimatsu, Y., et al. 2012. Mol Pharmacol. 82: 1042-55. PMID: 22923500
- Protection against oxidative stress in beta thalassemia/hemoglobin E erythrocytes by inhibitors of glutathione efflux transporters. | Muanprasat, C., et al. 2013. PLoS One. 8: e55685. PMID: 23383265
- Revisiting CFTR inhibition: a comparative study of CFTRinh -172 and GlyH-101 inhibitors. | Melis, N., et al. 2014. Br J Pharmacol. 171: 3716-27. PMID: 24758416
- Luminal acetylcholine does not affect the activity of the CFTR in tracheal epithelia of pigs. | Dittrich, NP., et al. 2015. Int Immunopharmacol. 29: 166-72. PMID: 26286842
- Increasing Sphingolipid Synthesis Alleviates Airway Hyperreactivity. | Heras, AF., et al. 2020. Am J Respir Cell Mol Biol. 63: 690-698. PMID: 32706610
- CFTR limits F-actin formation and promotes morphological alignment with flow in human lung microvascular endothelial cells. | Causer, AJ., et al. 2021. Physiol Rep. 9: e15128. PMID: 34851051
- Functional evaluation of the cystic fibrosis transmembrane conductance regulator in the endocervix†. | Han, L., et al. 2022. Biol Reprod. 107: 732-740. PMID: 35532160
Inhibitor of:
CFTR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CFTR Inhibitor II, GlyH-101, 5 mg | sc-221418 | 5 mg | $270.00 |