α4a Tubulin Inhibitors
α4a tubulin inhibitors belong to a chemical class of compounds that target the α4a isoform of tubulin, a crucial protein involved in microtubule assembly and dynamics within cells. Microtubules are fundamental components of the cellular cytoskeleton and play essential roles in various cellular processes, including cell division, intracellular transport, and maintenance of cell shape. The α4a tubulin isoform is a specific variant of tubulin present in cells and is one of the multiple isoforms that make up microtubules. These inhibitors are designed to specifically interact with and disrupt the function of α4a tubulin, leading to alterations in microtubule dynamics. The microtubule structure is composed of tubulin heterodimers, consisting of α-tubulin and β-tubulin subunits. The α-tubulin subunit, specifically the α4a isoform, plays a crucial role in the initiation of microtubule assembly. α4a tubulin inhibitors act by binding to the α4a tubulin subunit, which interferes with the formation of stable microtubule polymers. By inhibiting microtubule assembly, these compounds effectively destabilize the microtubule structure, preventing the formation of functional microtubules and disrupting their dynamic behavior.
The disruption of microtubule dynamics caused by α4a tubulin inhibitors has significant implications for cellular processes that depend on proper microtubule function. For instance, during cell division, microtubules are essential for the formation of the mitotic spindle, which segregates chromosomes accurately into daughter cells. By interfering with this process, α4a tubulin inhibitors can induce cell cycle arrest and hinder cell division. Moreover, microtubules are critical for intracellular transport processes, facilitating the movement of organelles, vesicles, and other cellular cargo. By targeting α4a tubulin, these inhibitors can impair intracellular transport, leading to disruptions in cellular trafficking and potentially affecting various cellular functions and signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
A well-known microtubule destabilizer and α4a tubulin inhibitor that interferes with microtubule assembly and leads to mitotic arrest in cells. | ||||||
Vinblastine Sulfate | 143-67-9 | sc-201447 sc-201447A sc-201447B sc-201447C | 10 mg 50 mg 100 mg 1 g | $109.00 $412.00 $561.00 $2244.00 | 9 | |
An anti-cancer drug found in the periwinkle plant (Vinca rosea). It inhibits microtubule polymerization and disrupts mitotic spindle formation. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
A natural compound found in the autumn crocus (Colchicum autumnale). It binds to tubulin and prevents microtubule polymerization. | ||||||
Estramustine | 2998-57-4 | sc-353281 sc-353281A | 100 mg 1 g | $265.00 $743.00 | ||
An anti-cancer drug that combines the hormone estradiol with the microtubule inhibitor nitrogen mustard. It affects microtubule dynamics in cancer cells. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
A natural compound found in the Mayapple plant (Podophyllum peltatum). Its derivatives, such as etoposide and teniposide, are used in cancer chemotherapy to inhibit microtubules. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
An antifungal agent that interferes with microtubule function in fungi. | ||||||
Albendazole | 54965-21-8 | sc-210771 | 100 mg | $213.00 | 1 | |
An anthelmintic agent used to fight parasitic worm infections by disrupting microtubules in worms. | ||||||
Thiabendazole | 148-79-8 | sc-204913 sc-204913A sc-204913B sc-204913C sc-204913D | 10 g 100 g 250 g 500 g 1 kg | $32.00 $84.00 $183.00 $312.00 $572.00 | 5 | |
An anthelmintic and antifungal drug with microtubule-inhibiting properties. | ||||||
Docetaxel | 114977-28-5 | sc-201436 sc-201436A sc-201436B | 5 mg 25 mg 250 mg | $87.00 $332.00 $1093.00 | 16 | |
A semi-synthetic taxane derivative used in cancer chemotherapy. It stabilizes microtubules and prevents their depolymerization. | ||||||