Smad1 Antibody (913C1b): sc-81378

Smad1 Antibody (913C1b) is a mouse monoclonal IgG1 antibody raised against a recombinant protein corresponding to an internal region of human Smad1, reacting with mouse, rat, and human proteins. Smad1, also known as Mothers against decapentaplegic homolog 1 (MADH1), JV4-1, or MADR1, is an intracellular signal transducer and transcriptional modulator involved in the Bone Morphogenetic Protein (BMP) pathway, part of the Transforming Growth Factor-beta (TGF-β) superfamily. Upon activation by BMP receptors, Smad1 is phosphorylated and forms a complex with Smad4, translocating from the cytoplasm to the nucleus. This nuclear localization is crucial because Smad1 regulates the expression of target genes that control cell proliferation, differentiation, and apoptosis. Smad1 function is essential for embryonic development, tissue homeostasis, and bone formation. Dysregulation of Smad1 signaling has been implicated in various diseases, including cancer and fibrosis. Smad1 (913C1b) antibody aids in studying the BMP signaling pathway and its impact on cellular processes. Anti-Smad1 antibody (913C1b) is suitable for applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM), providing a valuable tool for researchers investigating Smad1′s role in health and disease.

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Smad1 Antibody (913C1b) References:

1. Smad1 expression in follicular lymphoma.  |  Go, JH. 2015. J Pathol Transl Med. 49: 243-8. PMID: 26018516
2. Smad1 promotes colorectal cancer cell migration through Ajuba transactivation.  |  Yang, D., et al. 2017. Oncotarget. 8: 110415-110425. PMID: 29299158
3. SMAD1 as a biomarker and potential therapeutic target in drug-resistant multiple myeloma.  |  Wu, J., et al. 2021. Biomark Res. 9: 48. PMID: 34134766
4. 17β-estradiol promotes angiogenesis through non-genomic activation of Smad1 signaling in endometriosis.  |  Zhao, X., et al. 2022. Vascul Pharmacol. 142: 106932. PMID: 34763099
5. SMAD1 Loss-of-Function Variant Responsible for Congenital Heart Disease.  |  Wang, Z., et al. 2022. Biomed Res Int. 2022: 9916325. PMID: 35281600
6. Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer.  |  Shonibare, Z., et al. 2022. Cell Rep. 40: 111066. PMID: 35905726
7. Downregulation of METTL14 improves postmenopausal osteoporosis via IGF2BP1 dependent posttranscriptional silencing of SMAD1.  |  Huang, C. and Wang, Y. 2022. Cell Death Dis. 13: 919. PMID: 36319624
8. The Interaction Between SMAD1 and YAP1 Is Correlated with Increased Resistance of Gastric Cancer Cells to Cisplatin.  |  Chen, W., et al. 2023. Appl Biochem Biotechnol. 195: 6050-6067. PMID: 36418715
9. ZSWIM4 regulates embryonic patterning and BMP signaling by promoting nuclear Smad1 degradation.  |  Wang, C., et al. 2024. EMBO Rep. 25: 646-671. PMID: 38177922
10. Control of neuronal excitation-inhibition balance by BMP-SMAD1 signalling.  |  Okur, Z., et al. 2024. Nature. 629: 402-409. PMID: 38632412

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Smad1 Antibody (913C1b) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-Smad1 Antibody (913C1b) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Smad1 Antibody (913C1b) Specifications

Alternate Product Name: Smad1

Product Clone Name: 913C1b

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Smad1

Epitope Species: human

Product Reactivity/Detection: Smad1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, FCM

Vialing Information: Each vial contains 50 µg IgG₁ in 0.5 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for Smad1 Antibody (913C1b): N/A

The preferred Smad1 antibody is Smad1 Antibody (A-4): sc-7965.