caspase-14 Antibody (C-12): sc-48395
- caspase-14 Antibody (C-12) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 24-122 of caspase-14 of human origin
- recommended for detection of caspase-14 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for caspase-14 Antibody (C-12) for WB applications. These reagents are now offered in bundles with caspase-14 Antibody (C-12) (see ordering information below).
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SEE ALSO...
Caspase-14 Antibody (C-12) is a mouse monoclonal IgG2a antibody that detects caspase-14 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Caspase-14 is a unique member of the Ced-3/caspase family, which plays a crucial role in the apoptotic process by selectively cleaving specific target proteins that are vital for cellular longevity. Notably, caspase-14 is highly expressed in embryonic tissues, indicating its importance during development, but is largely absent in adult tissues, suggesting a specialized function in early life stages. Caspase-14 can be processed in vitro by caspase-8 and caspase-10, highlighting potential interactions within the apoptotic signaling pathways. The ability of caspase-14 to generate apoptotic fragments underscores its significance in regulating cell death and maintaining tissue homeostasis. Anti-caspase-14 antibody (C-12) is an essential tool for researchers studying apoptosis and its implications in various diseases, including cancer and neurodegenerative disorders.
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caspase-14 Antibody (C-12) References:
- Caspase-14 expression in the human placenta. | Kam, DW., et al. 2005. Reprod Biomed Online. 11: 236-43. PMID: 16168224
- Caspase-14 and epidermis maturation. | Nicotera, P. and Melino, G. 2007. Nat Cell Biol. 9: 621-2. PMID: 17541415
- Caspase-14 reveals its secrets. | Denecker, G., et al. 2008. J Cell Biol. 180: 451-8. PMID: 18250198
- Caspase-14 is an anti-apoptotic protein targeting apoptosis-inducing factor in lung adenocarcinomas. | Fang, HY., et al. 2011. Oncol Rep. 26: 359-69. PMID: 21567094
- Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin. | Hoste, E., et al. 2011. J Invest Dermatol. 131: 2233-41. PMID: 21654840
- Caspase-14 protocols. | Yamamoto-Tanaka, M. and Hibino, T. 2014. Methods Mol Biol. 1133: 89-100. PMID: 24567096
- Caspase-14 expression impairs retinal pigment epithelium barrier function: potential role in diabetic macular edema. | Beasley, S., et al. 2014. Biomed Res Int. 2014: 417986. PMID: 25121097
- Sphingoid Base-Upregulated Caspase-14 Expression Involves MAPK. | Nagahara, Y., et al. 2018. Biol Pharm Bull. 41: 743-748. PMID: 29709911
- Caspase-14-From Biomolecular Basics to Clinical Approach. A Review of Available Data. | Markiewicz, A., et al. 2021. Int J Mol Sci. 22: PMID: 34070382
- mRNA expression of caspase 14 in skin epithelial malignancies. | Markiewicz, A., et al. 2023. Postepy Dermatol Alergol. 40: 315-320. PMID: 37312914
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
caspase-14 Antibody (C-12) | sc-48395 | 200 µg/ml | $322.00 | |||
caspase-14 Antibody (C-12): m-IgG Fc BP-HRP Bundle | sc-536828 | 200 µg Ab; 10 µg BP | $361.00 | |||
caspase-14 Antibody (C-12): m-IgGκ BP-HRP Bundle | sc-533995 | 200 µg Ab; 40 µg BP | $361.00 | |||
caspase-14 Antibody (C-12): m-IgG2a BP-HRP Bundle | sc-547878 | 200 µg Ab; 10 µg BP | $361.00 |