Cyclin J Activators are a class of chemical compounds meticulously selected to enhance the functional activity of cyclin J (CCNJ). Cyclin J, a protein intricately involved in cell cycle regulation and various cellular processes, can be indirectly activated through the careful modulation of specific signaling pathways and biological processes. These activators, such as Resveratrol, exert their influence on cyclin J through the SIRT1 pathway, enhancing cell cycle regulation and cellular functions governed by cyclin J. Fasudil, on the other hand, enhances cyclin J's function by modulating Rho-associated protein kinase (ROCK), impacting cellular processes where cyclin J plays a vital role. Quercetin activates cyclin J indirectly by influencing the AMPK signaling pathway, promoting its involvement in cell cycle regulation and other cellular functions. SB216763 boosts cyclin J's function by inhibiting GSK-3β, indirectly affecting cellular processes linked to cyclin J. Additionally, compounds like MK-2206 enhance cyclin J activity by inhibiting Akt, a protein closely connected to cyclin J-regulated cellular functions and cell cycle regulation. PD98059 activates cyclin J by inhibiting MEK1/2 and subsequently promoting MAPK signaling, which is intricately linked with cyclin J's functions.
Furthermore, Y-27632 boosts cyclin J's activity by inhibiting Rho-associated protein kinase (ROCK), indirectly influencing cellular processes where cyclin J is a key player. Hesperidin enhances cyclin J function by indirectly affecting the PI3K/Akt pathway, which plays a crucial role in cellular processes associated with cyclin J. NSC 66811 activates cyclin J by influencing the Wnt signaling pathway, which intersects with cyclin J-regulated cellular functions and cell cycle regulation. BI-2536, through its impact on Plk1, enhances cyclin J's activity, particularly in cellular processes like cell cycle progression. AZD8055 boosts cyclin J function by inhibiting mTOR, indirectly affecting cellular processes linked to cyclin J. Finally, Naringenin activates cyclin J through the AMPK signaling pathway, indirectly promoting its role in cell cycle regulation and various cellular functions. In summary, Cyclin J Activators represent a versatile set of compounds that offer precise tools for researchers aiming to explore the roles of cyclin J in cell biology and cell cycle regulation.
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Nome do Produto | CAS # | Numero de Catalogo | Quantidade | Preco | Uso e aplicacao | NOTAS |
---|---|---|---|---|---|---|
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
Inibe as cinases da família Src, alterando potencialmente o estado de fosforilação das proteínas que interagem com o STYX. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Ativa a ciclina J indiretamente ao influenciar a via SIRT1, levando a uma melhor regulação do ciclo celular e a funções celulares que envolvem a ciclina J. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Inibe a PI3K, o que pode afetar as vias de sinalização a jusante em que o STYX está envolvido. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Ativa a ciclina J através da via de sinalização AMPK, promovendo indiretamente o seu papel na regulação do ciclo celular e nas funções celulares. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
Inibe a p38 MAP quinase, que pode modificar o contexto celular em que o STYX actua. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $70.00 $198.00 | 18 | |
Aumenta a função da ciclina J ao inibir a GSK-3β, afectando indiretamente os processos celulares em que a ciclina J desempenha um papel fundamental. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
Inibe a JNK, o que pode afetar as vias de sinalização ligadas à STYX. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $178.00 $325.00 | 67 | |
Aumenta a atividade da ciclina J através da inibição da Akt, uma proteína ligada às funções celulares reguladas pela ciclina J e à regulação do ciclo celular. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Inibe a PI3K, afectando as vias de sinalização e as interações proteicas que envolvem a STYX. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Aumenta a atividade da ciclina J através da inibição da proteína cinase associada à Rho (ROCK), afectando indiretamente os processos celulares em que a ciclina J está envolvida. |