ANKRD18A inhibitors represent a specialized class of chemical compounds designed to modulate the activity of the ANKRD18A protein, which is involved in various cellular processes. This protein, characterized by the presence of ankyrin repeat domains, plays a crucial role in protein-protein interactions and the regulation of cellular signaling pathways. ANKRD18A inhibitors typically feature a diverse range of chemical structures, often comprising heterocyclic rings, aromatic systems, and specific functional groups that enhance binding affinity and selectivity for the target protein. The design of these inhibitors focuses on optimizing their interaction with the ANKRD18A protein, often employing techniques such as molecular docking and structure-activity relationship studies to identify optimal chemical scaffolds.
The approaches to creating ANKRD18A inhibitors often involve advanced chemistry methods, including multi-step synthesis and combinatorial chemistry. These inhibitors may exhibit varying degrees of potency and specificity, which are essential for understanding the biological roles of ANKRD18A in cellular contexts. Furthermore, the study of these compounds contributes to the broader understanding of cellular mechanisms by providing tools to dissect the functions of ANKRD18A. Research into this chemical class also involves examining the physicochemical properties of the compounds, such as solubility, stability, and permeability, to ensure their suitability for experimental applications. As a result, ANKRD18A inhibitors serve as valuable resources for researchers investigating the fundamental biology of the ANKRD18A protein and its involvement in various cellular processes.
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Nome do Produto | CAS # | Numero de Catalogo | Quantidade | Preco | Uso e aplicacao | NOTAS |
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Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Este antibiótico liga-se ao ADN e inibe a ARN polimerase, diminuindo potencialmente a síntese do ARNm do ANKRD18A. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Este composto inibe a síntese proteica ao bloquear a translocação durante a tradução, reduzindo potencialmente os níveis da proteína ANKRD18A. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Como inibidor de mTOR, a rapamicina regula negativamente as vias de síntese proteica, o que pode afetar a expressão de ANKRD18A. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Este análogo da citidina afecta a metilação do ADN, o que pode levar a uma alteração da expressão de genes, incluindo o ANKRD18A. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Ao inibir as histonas desacetilases, afecta a estrutura da cromatina e a expressão dos genes, tendo um impacto potencial nos níveis de ANKRD18A. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
Esta toxina inibe a RNA polimerase II, reduzindo potencialmente a transcrição do gene ANKRD18A. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
Inibe a inosina monofosfato desidrogenase, afectando a síntese de nucleótidos e reduzindo potencialmente a síntese de ARN, incluindo a do ANKRD18A. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Este antibiótico inibe a formação de ligações peptídicas nos ribossomas, o que diminuiria a síntese global de proteínas, incluindo a ANKRD18A. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Inibe a topoisomerase I do ADN, que é necessária para a replicação e transcrição do ADN, afectando potencialmente a expressão de ANKRD18A. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
Este composto inibe seletivamente a RNA polimerase II, o que pode levar à diminuição da transcrição do gene ANKRD18A. |