ZWINT Antibody (A-7): sc-271646
- ZWINT Antibody (A-7) is a mouse monoclonal IgG1 κ ZWINT antibody provided at 200 µg/ml
- raised against amino acids 1-252 representing full length ZWINT of mouse origin
- ZWINT Antibody (A-7) is recommended for detection of ZWINT of mouse and rat origin by WB, IP, IF and ELISA
- Anti-ZWINT Antibody (A-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ZWINT Antibody (A-7) for WB applications. These reagents are now offered in bundles with ZWINT Antibody (A-7) (see ordering information below).
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SEE ALSO...
ZWINT Antibody (A-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects ZWINT of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ZWINT antibody (A-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ZWINT, also known as KNTC2AP or HZwint-1, is a 277 amino acid protein crucial for proper kinetochore function, which is essential for accurate chromosome segregation during cell division. ZWINT is localized to the cytoplasm during interphase and translocates to kinetochores from late prophase to anaphase, where ZWINT interacts with ZW10 (Zeste White 10) to regulate the association between ZW10 and kinetochores. Such interaction is vital for the formation of a kinetochore complex that includes other key proteins such as MIS12 (MIND kinetochore complex component) and PMF-1 (polyamine-modulated factor 1), all working together to ensure proper kinetochore assembly and spindle checkpoint activity. Defects in the gene encoding ZWINT have been linked to Roberts syndrome, an autosomal recessive disorder characterized by growth retardation due to premature chromosome separation, highlighting ZWINT′s critical role in maintaining genomic stability.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ZWINT Antibody (A-7) | sc-271646 | 200 µg/ml | $322.00 | |||
ZWINT Antibody (A-7): m-IgG Fc BP-HRP Bundle | sc-529232 | 200 µg Ab; 10 µg BP | $361.00 | |||
ZWINT Antibody (A-7): m-IgGκ BP-HRP Bundle | sc-522009 | 200 µg Ab, 40 µg BP | $361.00 | |||
ZWINT Antibody (A-7): m-IgG1 BP-HRP Bundle | sc-543402 | 200 µg Ab; 20 µg BP | $361.00 | |||
ZWINT Antibody (A-7) AC | sc-271646 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ZWINT Antibody (A-7) HRP | sc-271646 HRP | 200 µg/ml | $322.00 | |||
ZWINT Antibody (A-7) FITC | sc-271646 FITC | 200 µg/ml | $336.00 | |||
ZWINT Antibody (A-7) PE | sc-271646 PE | 200 µg/ml | $349.00 | |||
ZWINT Antibody (A-7) Alexa Fluor® 488 | sc-271646 AF488 | 200 µg/ml | $364.00 | |||
ZWINT Antibody (A-7) Alexa Fluor® 546 | sc-271646 AF546 | 200 µg/ml | $364.00 | |||
ZWINT Antibody (A-7) Alexa Fluor® 594 | sc-271646 AF594 | 200 µg/ml | $364.00 | |||
ZWINT Antibody (A-7) Alexa Fluor® 647 | sc-271646 AF647 | 200 µg/ml | $364.00 | |||
ZWINT Antibody (A-7) Alexa Fluor® 680 | sc-271646 AF680 | 200 µg/ml | $364.00 | |||
ZWINT Antibody (A-7) Alexa Fluor® 790 | sc-271646 AF790 | 200 µg/ml | $364.00 |