ZNF3 Antibody (H-10): sc-376519

ZNF3 Antibody (H-10) is a mouse monoclonal IgG2b kappa light chain antibody that detects ZNF3 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ZNF3 (H-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ZNF3, also known as KOX25, is a member of the Kruppel C(2)H(2)-type zinc finger protein family and plays a crucial role in regulating gene expression through DNA-binding capabilities. ZNF3 is primarily located in the nucleus, where ZNF3 is involved in essential cellular processes such as differentiation and proliferation. ZNF3 structure includes eight C(2)H(2)-type zinc fingers and one KRAB domain, which enables interaction with transcriptional co-repressors like KAP1, thereby influencing chromatin remodeling and gene silencing. These zinc fingers are vital for binding specific DNA sequences, making ZNF3 an important player in regulating genes associated with development and cellular response to stimuli. ZNF3 is encoded by a gene located in a cluster of KOX zinc-finger genes on chromosome 10, highlighting evolutionary significance and potential implications in various biological processes.

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ZNF3 Antibody (H-10) References:

1. The KOX zinc finger genes: genome wide mapping of 368 ZNF PAC clones with zinc finger gene clusters predominantly in 23 chromosomal loci are confirmed by human sequences annotated in EnsEMBL.  |  Rousseau-Merck, MF., et al. 2002. Cytogenet Genome Res. 98: 147-53. PMID: 12697996
2. The KRAB domain of zinc finger gene ZNF268: a potential transcriptional repressor.  |  Sun, Y., et al. 2003. IUBMB Life. 55: 127-31. PMID: 12822888
3. Conservation, diversification and expansion of C2H2 zinc finger proteins in the Arabidopsis thaliana genome.  |  Englbrecht, CC., et al. 2004. BMC Genomics. 5: 39. PMID: 15236668
4. A novel subfamily of zinc finger genes involved in embryonic development.  |  Nakamura, M., et al. 2004. J Cell Biochem. 93: 887-95. PMID: 15449319
5. A novel zinc-finger protein ZNF436 suppresses transcriptional activities of AP-1 and SRE.  |  Li, Y., et al. 2006. Mol Biol Rep. 33: 287-94. PMID: 17089209
6. Genome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFs.  |  O'Geen, H., et al. 2007. PLoS Genet. 3: e89. PMID: 17542650
7. Identification of a novel human zinc finger gene, ZNF438, with transcription inhibition activity.  |  Zhong, Z., et al. 2007. J Biochem Mol Biol. 40: 517-24. PMID: 17669267

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ZNF3 Antibody (H-10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ZNF3 Antibody (H-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ZNF3 Antibody (H-10) Specifications

Alternate Product Name: ZNF3

Product Clone Name: H-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 106-214

Epitope Target: ZNF3

Epitope Species: human

Product Reactivity/Detection: ZNF3

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ZNF3 Antibody (H-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent