ZIP1 Antibody (F-2): sc-393345
- ZIP1 Antibody (F-2) is a mouse monoclonal IgG2a κ ZIP1 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 83-192 mapping within an internal region of ZIP1 of human origin
- ZIP1 Antibody (F-2) is recommended for detection of ZIP1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-ZIP1 Antibody (F-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ZIP1 Antibody (F-2) for WB applications. These reagents are now offered in bundles with ZIP1 Antibody (F-2) (see ordering information below).
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ZIP1 Antibody (F-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects ZIP1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-ZIP1 antibody (F-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ZIP1, also known as SLC39A1 (solute carrier family 39, zinc transporter, member 1), IRT1, or ZIRTL, is a 324 amino acid multi-pass membrane protein that plays a critical role in zinc transport across cell membranes, which is essential for numerous cellular functions. ZIP1 is predominantly located in the cell membrane and endoplasmic reticulum, where ZIP1 facilitates zinc uptake, an essential cofactor involved in cell growth, development, and metabolism of proteins, nucleic acids, and lipids. Proper localization and function of ZIP1 are vital, as zinc transport is crucial for enzyme activity and overall cellular health. Dysregulation of ZIP1 may contribute to various diseases, including prostate cancer, highlighting ZIP1′s importance in maintaining zinc homeostasis within prostate cells.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ZIP1 Antibody (F-2) References:
- Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex. | Lioumi, M., et al. 1999. Genomics. 62: 272-80. PMID: 10610721
- Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells. | Franklin, RB., et al. 2003. J Inorg Biochem. 96: 435-42. PMID: 12888280
- hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer. | Franklin, RB., et al. 2005. Mol Cancer. 4: 32. PMID: 16153295
- Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells. | Tang, Z., et al. 2006. Bone. 38: 181-98. PMID: 16203195
- A di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein. | Huang, L. and Kirschke, CP. 2007. FEBS J. 274: 3986-97. PMID: 17635580
- Zinc supplementation in the elderly reduces spontaneous inflammatory cytokine release and restores T cell functions. | Kahmann, L., et al. 2008. Rejuvenation Res. 11: 227-37. PMID: 18279033
- Overexpression of the zinc uptake transporter hZIP1 inhibits nuclear factor-kappaB and reduces the malignant potential of prostate cancer cells in vitro and in vivo. | Golovine, K., et al. 2008. Clin Cancer Res. 14: 5376-84. PMID: 18765529
- Transcriptional regulation of the major zinc uptake protein hZip1 in prostate cancer cells. | Makhov, P., et al. 2009. Gene. 431: 39-46. PMID: 19026724
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ZIP1 Antibody (F-2) | sc-393345 | 200 µg/ml | $322.00 | |||
ZIP1 Antibody (F-2): m-IgG Fc BP-HRP Bundle | sc-530433 | 200 µg Ab; 10 µg BP | $361.00 | |||
ZIP1 Antibody (F-2): m-IgGκ BP-HRP Bundle | sc-523911 | 200 µg Ab, 40 µg BP | $361.00 | |||
ZIP1 Antibody (F-2): m-IgG2a BP-HRP Bundle | sc-547500 | 200 µg Ab; 10 µg BP | $361.00 | |||
ZIP1 Antibody (F-2) AC | sc-393345 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ZIP1 Antibody (F-2) HRP | sc-393345 HRP | 200 µg/ml | $322.00 | |||
ZIP1 Antibody (F-2) FITC | sc-393345 FITC | 200 µg/ml | $336.00 | |||
ZIP1 Antibody (F-2) PE | sc-393345 PE | 200 µg/ml | $349.00 | |||
ZIP1 Antibody (F-2) Alexa Fluor® 488 | sc-393345 AF488 | 200 µg/ml | $364.00 | |||
ZIP1 Antibody (F-2) Alexa Fluor® 546 | sc-393345 AF546 | 200 µg/ml | $364.00 | |||
ZIP1 Antibody (F-2) Alexa Fluor® 594 | sc-393345 AF594 | 200 µg/ml | $364.00 | |||
ZIP1 Antibody (F-2) Alexa Fluor® 647 | sc-393345 AF647 | 200 µg/ml | $364.00 | |||
ZIP1 Antibody (F-2) Alexa Fluor® 680 | sc-393345 AF680 | 200 µg/ml | $364.00 | |||
ZIP1 Antibody (F-2) Alexa Fluor® 790 | sc-393345 AF790 | 200 µg/ml | $364.00 |