ZBP-89 Antibody (E-7): sc-137169

ZBP-89 Antibody (E-7) is a mouse monoclonal IgG1 antibody that detects ZBP-89 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ZBP-89, also known as BFCOL1, BERF1, and ZNF 148, is a zinc finger transcription factor that plays a crucial role in regulating gene expression, particularly as a silencer element binding factor for Vimentin. ZBP-89 is universally expressed and functions as a Kruppel-like repressor, binding to GC-rich DNA elements in the promoters of key genes such as gastrin, ornithine decarboxylase, and the cyclin-dependent kinase inhibitor p21, which is a significant target gene of the tumor suppressor p53. ZBP-89′s interaction with p53 is particularly important, as this interaction not only regulates cell proliferation but also influences the cellular response to stress by retarding the nuclear export of p53, thereby enhancing tumor-suppressive functions. ZBP-89 expression can be induced by agents like trans-retinoic acid or butyrate, which are known to promote terminal differentiation in colon cancer cells, highlighting a potential role in cancer biology. Elevated levels of ZBP-89 have been associated with growth arrest and apoptosis in human gastrointestinal cells, making ZBP-89 a critical factor in understanding cellular mechanisms related to cancer and differentiation.

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ZBP-89 Antibody (E-7) References:

1. Transcription factor ZBP-89 in cancer growth and apoptosis.  |  Zhang, CZ., et al. 2010. Biochim Biophys Acta. 1806: 36-41. PMID: 20230874
2. Role of ZBP-89 in human globin gene regulation and erythroid differentiation.  |  Woo, AJ., et al. 2011. Blood. 118: 3684-93. PMID: 21828133
3. Interaction between ZBP-89 and p53 mutants and its contribution to effects of HDACi on hepatocellular carcinoma.  |  Zhang, CZ., et al. 2012. Cell Cycle. 11: 322-34. PMID: 22214764
4. ZBP-89 reduces histone deacetylase 3 by degrading IkappaB in the presence of Pin1.  |  Ye, CG., et al. 2015. J Transl Med. 13: 23. PMID: 25623232
5. Zinc-binding protein-89 (ZBP-89) cooperates with NF-κB to regulate expression of matrix metalloproteinases (MMPs) in response to inflammatory cytokines.  |  Borghaei, RC., et al. 2016. Biochem Biophys Res Commun. 471: 503-9. PMID: 26891870
6. Transcription Factor ZBP-89 Drives a Feedforward Loop of β-Catenin Expression in Colorectal Cancer.  |  Essien, BE., et al. 2016. Cancer Res. 76: 6877-6887. PMID: 27758879
7. ZBP-89 and Sp1 contribute to Bak expression in hepatocellular carcinoma cells.  |  Kong, X., et al. 2018. BMC Cancer. 18: 419. PMID: 29653560
8. Targeting ZBP-89 for the treatment of hepatocellular carcinoma.  |  Wang, N., et al. 2018. Expert Opin Ther Targets. 22: 817-822. PMID: 30142986
9. ZBP-89 negatively regulates self-renewal of liver cancer stem cells via suppression of Notch1 signaling pathway.  |  Wang, N., et al. 2020. Cancer Lett. 472: 70-80. PMID: 31874246
10. ZBP-89, a Krüppel-like zinc finger protein, inhibits epidermal growth factor induction of the gastrin promoter.  |  Merchant, JL., et al. 1996. Mol Cell Biol. 16: 6644-53. PMID: 8943318

The preferred ZBP-89 antibody is ZBP-89 Antibody (H-7): sc-137171.