YY1 Antibody (H-10): sc-7341

YY1 Antibody (H-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects YY1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry (IHC), and enzyme-linked immunosorbent assay (ELISA). YY1 Antibody (H-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase, phycoerythrin, fluorescein isothiocyanate, and multiple Alexa Fluor® conjugates. YY1 monoclonal antibody (H-10) recognizes YY1 transcription factor, also known as NF-E1 in humans and Delta or UCRBP in mice. YY1 (H-10) antibody targets a protein that plays a crucial role in regulating diverse target genes, making YY1 essential for various biological processes. YY1 is located in the nucleus, where YY1 interacts with DNA to modulate gene expression. Four C-terminal zinc finger motifs and unique structural features at N-terminal enhance YY1′s versatility as a transcriptional regulator. Dual functionality as both an activator and repressor of transcription highlights YY1′s importance in maintaining cellular homeostasis and responding to developmental cues. This multifaceted role underscores YY1′s significance in both normal physiology and disease states, making YY1 (H-10) monoclonal antibody a valuable tool for researchers studying gene regulation and transcriptional dynamics.

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YY1 Antibody (H-10) References:

1. Cloning of a negative transcription factor that binds to the upstream conserved region of Moloney murine leukemia virus.  |  Flanagan, JR., et al. 1992. Mol Cell Biol. 12: 38-44. PMID: 1309593
2. Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein.  |  Shi, Y., et al. 1991. Cell. 67: 377-88. PMID: 1655281
3. Common factor 1 is a transcriptional activator which binds in the c-myc promoter, the skeletal alpha-actin promoter, and the immunoglobulin heavy-chain enhancer.  |  Riggs, KJ., et al. 1991. Mol Cell Biol. 11: 1765-9. PMID: 1899910
4. Delta, a transcription factor that binds to downstream elements in several polymerase II promoters, is a functionally versatile zinc finger protein.  |  Hariharan, N., et al. 1991. Proc Natl Acad Sci U S A. 88: 9799-803. PMID: 1946404
5. Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site.  |  Park, K. and Atchison, ML. 1991. Proc Natl Acad Sci U S A. 88: 9804-8. PMID: 1946405
6. YY1 Is a Structural Regulator of Enhancer-Promoter Loops.  |  Weintraub, AS., et al. 2017. Cell. 171: 1573-1588.e28. PMID: 29224777
7. A histidine cluster determines YY1-compartmentalized coactivators and chromatin elements in phase-separated enhancer clusters.  |  Wang, W., et al. 2022. Nucleic Acids Res. 50: 4917-4937. PMID: 35390165
8. YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2.  |  Wang, X., et al. 2023. Genome Biol. 24: 87. PMID: 37085894
9. YY1 complex in M2 macrophage promotes prostate cancer progression by upregulating IL-6.  |  Chen, S., et al. 2023. J Immunother Cancer. 11: PMID: 37094986
10. A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury.  |  Yang, C., et al. 2023. Nat Commun. 14: 4261. PMID: 37460623
11. Interaction between transcription factors Sp1 and YY1.  |  Seto, E., et al. 1993. Nature. 365: 462-4. PMID: 8003102
12. Characterization of the mouse gene that encodes the delta/YY1/NF-E1/UCRBP transcription factor.  |  Sáfrány, G. and Perry, RP. 1993. Proc Natl Acad Sci U S A. 90: 5559-63. PMID: 8516301

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-YY1 Antibody (H-10) has 234 citations in a variety of scientific publications.

Primary antibodies like Anti-YY1 Antibody (H-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

YY1 Antibody (H-10) Specifications

Alternate Product Name: YY1

Product Clone Name: H-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-414

Epitope Target: YY1

Epitope Species: human

Product Reactivity/Detection: YY1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 234 citations in various scientific publications

Available Conjugates/Forms for YY1 Antibody (H-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent