XTP3TPA Antibody (B-6): sc-398501
- XTP3TPA Antibody (B-6) is a mouse monoclonal IgG2a κ XTP3TPA antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 59-125 mapping within an internal region of XTP3TPA of human origin
- XTP3TPA Antibody (B-6) is recommended for detection of XTP3TPA of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-XTP3TPA Antibody (B-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for XTP3TPA Antibody (B-6) for WB applications. These reagents are now offered in bundles with XTP3TPA Antibody (B-6) (see ordering information below).
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XTP3TPA Antibody (B-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects XTP3TPA protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). XTP3TPA Antibody (B-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The XTP3-transactivated gene A protein (XTP3TPA), also known as RS21-C6, is a 170 amino acid protein that exists as a homotetramer and features an epilepsy-associated repeat (EAR) domain, which spans approximately 44 amino acids and is crucial for protein-protein interactions, particularly in ligand recognition. XTP3TPA is predominantly expressed in embryonic and highly proliferating cells, with significant levels found in the liver, kidney, ovary, and testis, and is especially abundant in cancer cells. One of the key functions of XTP3TPA is hydrolyzing abnormal nucleotide triphosphates (NTPs) within cancer cells; if these NTPs are not regulated, they can be mistakenly incorporated into nascent DNA or RNA, potentially leading to genomic instability. XTP3TPA′s ability to manage these abnormal NTPs underscores its importance in maintaining cellular integrity and highlights its potential as a target for therapeutic interventions in cancer.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
XTP3TPA Antibody (B-6) References:
- [Prokaryotic expression, purification and preparation of polyclonal antibody and immunohistochemistry analysis of RS21-C6 molecule]. | Li, Y., et al. 2004. Beijing Da Xue Xue Bao Yi Xue Ban. 36: 268-71. PMID: 15205697
- Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential 'house-cleaning' functions. | Moroz, OV., et al. 2005. J Mol Biol. 347: 243-55. PMID: 15740738
- Towards a proteome-scale map of the human protein-protein interaction network. | Rual, JF., et al. 2005. Nature. 437: 1173-8. PMID: 16189514
- Mitogenic estrogen metabolites alter the expression of 17beta-estradiol-regulated proteins including heat shock proteins in human MCF-7 breast cancer cells. | Kim, SH., et al. 2005. Mol Cells. 20: 378-84. PMID: 16404153
- Protein profiling and transcript expression levels of heat shock proteins in 17beta-estradiol-treated human MCF-7 breast cancer cells. | Lee, SU., et al. 2006. Cell Biol Int. 30: 983-91. PMID: 16962797
- Crystal structure of RS21-C6, involved in nucleoside triphosphate pyrophosphohydrolysis. | Wu, B., et al. 2007. J Mol Biol. 367: 1405-12. PMID: 17320107
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
XTP3TPA Antibody (B-6) | sc-398501 | 200 µg/ml | $322.00 | |||
XTP3TPA Antibody (B-6): m-IgG Fc BP-HRP Bundle | sc-530824 | 200 µg Ab; 10 µg BP | $361.00 | |||
XTP3TPA Antibody (B-6): m-IgGκ BP-HRP Bundle | sc-524370 | 200 µg Ab, 40 µg BP | $361.00 | |||
XTP3TPA Antibody (B-6): m-IgG2a BP-HRP Bundle | sc-547603 | 200 µg Ab; 10 µg BP | $361.00 | |||
XTP3TPA Antibody (B-6) AC | sc-398501 AC | 500 µg/ml, 25% agarose | $424.00 | |||
XTP3TPA Antibody (B-6) HRP | sc-398501 HRP | 200 µg/ml | $322.00 | |||
XTP3TPA Antibody (B-6) FITC | sc-398501 FITC | 200 µg/ml | $336.00 | |||
XTP3TPA Antibody (B-6) PE | sc-398501 PE | 200 µg/ml | $349.00 | |||
XTP3TPA Antibody (B-6) Alexa Fluor® 488 | sc-398501 AF488 | 200 µg/ml | $364.00 | |||
XTP3TPA Antibody (B-6) Alexa Fluor® 546 | sc-398501 AF546 | 200 µg/ml | $364.00 | |||
XTP3TPA Antibody (B-6) Alexa Fluor® 594 | sc-398501 AF594 | 200 µg/ml | $364.00 | |||
XTP3TPA Antibody (B-6) Alexa Fluor® 647 | sc-398501 AF647 | 200 µg/ml | $364.00 | |||
XTP3TPA Antibody (B-6) Alexa Fluor® 680 | sc-398501 AF680 | 200 µg/ml | $364.00 | |||
XTP3TPA Antibody (B-6) Alexa Fluor® 790 | sc-398501 AF790 | 200 µg/ml | $364.00 |