XRN1 Antibody (G-2): sc-165984
- XRN1 Antibody (G-2) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 301-450 mapping within an internal region of XRN1 of human origin
- recommended for detection of XRN1 of mouse, rat and human origin by WB, IP, IF and ELISA
- See XRN1 (C-1): sc-165985 for XRN1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for XRN1 Antibody (G-2) for WB applications. These reagents are now offered in bundles with XRN1 Antibody (G-2) (see ordering information below).
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XRN1 Antibody (G-2) is a mouse monoclonal IgG1 antibody that detects Exoribonuclease I (XRN1) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). XRN1 is a crucial 1,694-amino acid protein that serves as the primary cytoplasmic 5′ to 3′ exoribonuclease, playing a vital role in the degradation of mRNA, which is essential for regulating gene expression and maintaining cellular homeostasis. Beyond its role in mRNA turnover, XRN1 is also implicated in the formation of stress granules and processing bodies, which are critical for managing cellular responses to stress and controlling mRNA stability. XRN1′s ability to induce the expression of these cytoplasmic aggregates highlights its importance in cellular stress responses, as XRN1 helps to sequester and protect mRNA during unfavorable conditions. Furthermore, the loss of XRN1 has been shown to significantly impair cell growth rates, underscoring its essential function in cellular metabolism and overall viability. Anti-XRN1 antibody (G-2) is an invaluable tool for researchers studying mRNA dynamics and the intricate mechanisms of gene regulation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
XRN1 Antibody (G-2) | sc-165984 | 200 µg/ml | $316.00 | |||
XRN1 Antibody (G-2): m-IgG Fc BP-HRP Bundle | sc-539978 | 200 µg Ab; 10 µg BP | $354.00 | |||
XRN1 Antibody (G-2): m-IgG1 BP-HRP Bundle | sc-541827 | 200 µg Ab; 20 µg BP | $354.00 |