XRCC4 Antibody (A-7): sc-365055

XRCC4 Antibody (A-7) is a mouse monoclonal IgG2b antibody that detects XRCC4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). XRCC4 plays a crucial role in the DNA repair process, specifically in the non-homologous end joining pathway, which is essential for repairing double-strand breaks in DNA. This function is vital for maintaining genomic stability, as unrepaired DNA breaks can lead to mutations, cancer, and cell death. XRCC4 acts as an accessory factor for DNA ligase IV, enhancing its ability to join DNA fragments with nicks or broken ends, thereby facilitating the repair process. Additionally, XRCC4 is involved in V(D)J recombination, a critical mechanism for generating diversity in immune responses. Deficiencies in XRCC4 or its interacting partners can result in severe immunodeficiency and increased susceptibility to cancer, highlighting the importance of this protein in both DNA repair and immune system functionality. Anti-XRCC4 antibody (A-7) is an invaluable tool for researchers studying DNA repair mechanisms and their implications in health and disease.

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XRCC4 Antibody (A-7) References:

1. Mutations in XRCC4 cause primary microcephaly, short stature and increased genomic instability.  |  Rosin, N., et al. 2015. Hum Mol Genet. 24: 3708-17. PMID: 25839420
2. In cellulo phosphorylation of XRCC4 Ser320 by DNA-PK induced by DNA damage.  |  Sharma, MK., et al. 2016. J Radiat Res. 57: 115-20. PMID: 26666690
3. FBXW7 Facilitates Nonhomologous End-Joining via K63-Linked Polyubiquitylation of XRCC4.  |  Zhang, Q., et al. 2016. Mol Cell. 61: 419-433. PMID: 26774286
4. Sliding sleeves of XRCC4-XLF bridge DNA and connect fragments of broken DNA.  |  Brouwer, I., et al. 2016. Nature. 535: 566-9. PMID: 27437582
5. Structural and functional characterization of the PNKP-XRCC4-LigIV DNA repair complex.  |  Aceytuno, RD., et al. 2017. Nucleic Acids Res. 45: 6238-6251. PMID: 28453785
6. XRCC4, which is inhibited by PFDA, regulates DNA damage repair and cell chemosensitivity.  |  Liu, F., et al. 2019. J Cell Biochem. 120: 12665-12676. PMID: 30834581
7. The XRCC4 rs1805377 polymorphism is not associated with the risk of cancer: An updated meta-analysis.  |  Zhang, XY., et al. 2020. J Int Med Res. 48: 300060520926364. PMID: 32493081
8. Functional analysis of XRCC4 mutations in reported microcephaly and growth defect patients in terms of radiosensitivity.  |  Asa, ADDC., et al. 2021. J Radiat Res. 62: 380-389. PMID: 33842963
9. Association of XRCC3, XRCC4, BAX, and BCL-2 Polymorphisms with the Risk of Breast Cancer.  |  Ozoran, E., et al. 2022. Int J Breast Cancer. 2022: 5817841. PMID: 35320970
10. Structural study of wild-type and phospho-mimic XRCC4 dimer and multimer proteins using circular dichroism spectroscopy.  |  Nishikubo, K., et al. 2023. Int J Radiat Biol. 99: 1684-1691. PMID: 37171809

The preferred XRCC4 antibody is XRCC4 Antibody (C-4): sc-271087.