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XRCC3 Antibody (10F1/6) - Western Blotting - Image 12795
XRCC3 Antibody (10F1/6): sc-53471. Western blot analysis of XRCC3 expression in HeLa nuclear extract under reducing (A) and non-reducing conditions (B).
XRCC3 Antibody (10F1/6) - Western Blotting - Image 12795
XRCC3 Antibody (10F1/6): sc-53471. Western blot analysis of XRCC3 expression in HeLa nuclear extract under reducing (A) and non-reducing conditions (B).
XRCC3 Antibody (10F1/6): sc-53471. Western blot analysis of XRCC3 expression in HeLa nuclear extract under reducing (A) and non-reducing conditions (B).

XRCC3 Antibody (10F1/6): sc-53471

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Datasheets
  • XRCC3 Antibody (10F1/6) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
  • raised against His-tagged recombinant human XRCC3
  • recommended for detection of XRCC3 of human origin by WB and IP
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for XRCC3 Antibody (10F1/6) for WB applications. These reagents are now offered in bundles with XRCC3 Antibody (10F1/6) (see ordering information below).
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Additional XRCC Antibodies including XRCC1, XRCC2 and XRCC4

XRCC3 Antibody (10F1/6) is a mouse monoclonal IgG1 kappa light chain antibody that detects XRCC3 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-XRCC3 antibody (10F1/6) plays a crucial role in the DNA repair process, specifically in the maintenance of genomic stability following DNA damage. XRCC3 (10F1/6) monoclonal antibody is primarily located in the nucleus, where XRCC3 is essential for the repair of DNA double-strand breaks through homologous recombination. This localization is vital because the nucleus is the site of DNA replication and repair, and any failure in these processes can lead to mutations, genomic instability, and ultimately contribute to the development of various diseases, including cancer. XRCC3 interacts directly with Rad51, a key protein in the homologous recombination repair pathway, facilitating the accurate repair of damaged DNA. By ensuring the integrity of the genetic material, XRCC3 is integral to cellular health and the prevention of tumorigenesis. Anti-XRCC3 antibody (10F1/6) effectively detects this crucial protein, making XRCC3 (10F1/6) antibody an invaluable tool for researchers studying DNA repair mechanisms and their implications in disease.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

XRCC3 Antibody (10F1/6) References:

  1. XRCC3 promotes homology-directed repair of DNA damage in mammalian cells.  |  Pierce, AJ., et al. 1999. Genes Dev. 13: 2633-8. PMID: 10541549
  2. XRCC3 5'-UTR and IVS5-14 polymorphisms and breast cancer susceptibility: a meta-analysis.  |  Qiu, LX., et al. 2010. Breast Cancer Res Treat. 122: 489-93. PMID: 20049524
  3. XRCC3 Thr241Met polymorphism and clinical outcomes of NSCLC patients receiving platinum-based chemotherapy: a systematic review and meta-analysis.  |  Shen, XY., et al. 2013. PLoS One. 8: e69553. PMID: 23940523
  4. XRCC3 Thr241Met polymorphism and gastric cancer susceptibility: a meta-analysis.  |  Qin, XP., et al. 2014. Clin Res Hepatol Gastroenterol. 38: 226-34. PMID: 24315014
  5. DNA repair gene XRCC3 Thr241Met polymorphisms and lung cancer risk: a meta-analysis.  |  Bei, L., et al. 2015. Bull Cancer. 102: 332-9. PMID: 25794597
  6. Associations between XRCC3 Thr241Met polymorphisms and breast cancer risk: systematic-review and meta-analysis of 55 case-control studies.  |  Dashti, S., et al. 2019. BMC Med Genet. 20: 79. PMID: 31077156
  7. Polymorphism of XRCC3 in Egyptian Breast Cancer Patients.  |  Alkasaby, MK., et al. 2020. Pharmgenomics Pers Med. 13: 273-282. PMID: 32821150
  8. Association between XRCC3 rs861539 Polymorphism and the Risk of Ovarian Cancer: Meta-Analysis and Trial Sequential Analysis.  |  Hu, S., et al. 2022. Biomed Res Int. 2022: 3915402. PMID: 35978646
  9. Association between XRCC3 p.Thr241Met polymorphism and risk of glioma: A systematic review and meta-analysis.  |  Tan, SC., et al. 2022. PLoS One. 17: e0276313. PMID: 36264998
  10. Association of XRCC3 18067 C>T (Thr241Met) polymorphism with risk of cervical and ovarian cancers: A systematic review and meta-analysis.  |  Karimi-Zarchi, M., et al. 2020. Interv Med Appl Sci. 11: 172-181. PMID: 36343295

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

XRCC3 Antibody (10F1/6)

sc-53471
200 µg/ml
$322.00

XRCC3 Antibody (10F1/6): m-IgG Fc BP-HRP Bundle

sc-536971
200 µg Ab; 10 µg BP
$361.00

XRCC3 Antibody (10F1/6): m-IgGκ BP-HRP Bundle

sc-534148
200 µg Ab; 40 µg BP
$361.00

XRCC3 Antibody (10F1/6): m-IgG1 BP-HRP Bundle

sc-544931
200 µg Ab; 20 µg BP
$361.00

What blocking solution should I use with XRCC3 (10F1/6): sc-53471 monoclonal antibody for Western blot?

Asked by: DefinitelyNotMatt
Thank you for your question. We recommend blocking with Blotto (either TBS Blotto A: sc-2333 or TBS Blotto B: sc-2335). Our Western blot protocol can be found here: https://www.scbt.com/scbt/resources/protocols/western-immuno-blotting
Answered by: Technical Support
Date published: 2017-04-12
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Rated 4 out of 5 by from WB publishable data with human U2OSWB publishable data with human U2OS, Saos2, HeLa - SCBT Publication Review
Date published: 2015-04-13
Rated 4 out of 5 by from Decent WB signal obtained using HeLa nuclearDecent WB signal obtained using HeLa nuclear extract under reducing and non-reducing conditions. -SCBT QC
Date published: 2015-01-18
  • y_2026, m_4, d_29, h_11
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XRCC3 Antibody (10F1/6) is rated 4.0 out of 5 by 2.
  • y_2026, m_4, d_29, h_11
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.43
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