XLF Antibody (E-2): sc-393844

XLF Antibody (E-2) is a mouse monoclonal IgG1 antibody that detects XLF in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). XLF, also known as non-homologous end-joining factor 1 (NHEJ1) or cernunnos, is a crucial 295 amino acid protein that plays a significant role in the non-homologous end-joining (NHEJ) pathway, which is essential for repairing DNA double-strand breaks. Anti-XLF antibody (E-2) recognizes a protein vital for maintaining genomic stability, as XLF allows cells to quickly and efficiently repair DNA damage that can lead to mutations or cell death. XLF is known to interact with DNA Ligase IV and XRCC4, forming a stable complex that is integral to the NHEJ machinery, thereby facilitating the final steps of DNA repair. Additionally, XLF exists in two isoforms due to alternative splicing, which may have implications for functional diversity and regulatory mechanisms in different cellular contexts. XLF monoclonal antibody (E-2) effectively detects this protein across various species, making XLF (E-2) antibody an invaluable tool for researchers studying DNA repair mechanisms and their implications in diseases such as cancer.

The preferred XLF antibody is XLF Antibody (D-1): sc-166488.