X11β Antibody (H-6): sc-376880

X11β Antibody (H-6) is a mouse monoclonal IgG1 antibody that detects X11β in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). X11β, a neuronal transmembrane protein, plays a crucial role in modulating the processing of the β-Amyloid precursor protein (β-APP), which is a significant factor in the pathogenesis of Alzheimer′s disease. By binding to the YENPTY motif of β-APP via its phosphotyrosine binding domain, X11β reduces the secretion of cellular β-APP and slows down its processing pathways, thereby influencing amyloid plaque formation. The interaction between X11β and β-APP is vital for maintaining cellular homeostasis and preventing the accumulation of toxic amyloid peptides. Additionally, multiple splice variants of X11, including X11α (Mint 1), X11β (Mint 2), and X11γ (Mint 3), have been identified, each contributing uniquely to the regulation of β-APP and its associated pathways. Anti-X11β antibody (H-6) is an essential tool for researchers investigating the molecular mechanisms underlying Alzheimer′s disease and the role of β-APP processing in neurodegeneration.

The preferred X11β antibody is X11β Antibody (B-5): sc-377060.