X11β Antibody (B-5): sc-377060

X11β Antibody (B-5) is a mouse monoclonal IgM antibody that detects X11 beta protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-X11 beta antibody (B-5) is available as the non-conjugated form. X11 beta protein plays a crucial role in the regulation of β-Amyloid precursor protein (β-APP), which is a significant component of amyloid plaques found in Alzheimer′s disease. By binding to β-APP through its phosphotyrosine binding (PTB) domain, X11 beta protein modulates the processing and secretion of β-APP, thereby influencing the accumulation of amyloid-beta peptides that contribute to neurodegeneration. The interaction of X11 with β-APP helps to slow down the pathways that lead to the production of these toxic peptides, highlighting X11 beta′s potential as a therapeutic target in Alzheimer′s disease. X11 beta protein interacts with various splice variants, including X11α (Mint 1) and X11γ (Mint 3), which may further diversify X11 beta′s functional roles in neuronal signaling and cellular processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

X11β Antibody (B-5) References:

1. The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.  |  Borg, JP., et al. 1996. Mol Cell Biol. 16: 6229-41. PMID: 8887653
2. Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain.  |  Zhang, Z., et al. 1997. EMBO J. 16: 6141-50. PMID: 9321393
3. Mints, Munc18-interacting proteins in synaptic vesicle exocytosis.  |  Okamoto, M. and Südhof, TC. 1997. J Biol Chem. 272: 31459-64. PMID: 9395480
4. The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion.  |  Borg, JP., et al. 1998. J Biol Chem. 273: 14761-6. PMID: 9614075
5. X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion.  |  Sastre, M., et al. 1998. J Biol Chem. 273: 22351-7. PMID: 9712855
6. Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor protein.  |  Russo, T., et al. 1998. FEBS Lett. 434: 1-7. PMID: 9738440

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-X11β Antibody (B-5) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-X11β Antibody (B-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

X11β Antibody (B-5) Specifications

Alternate Product Name: X11β

Product Clone Name: B-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 1-220

Epitope Target: X11β

Epitope Species: mouse

Product Reactivity/Detection: X11β

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for X11β Antibody (B-5): N/A