X11β Antibody (E-4): sc-376510

X11β Antibody (E-4) is a mouse monoclonal IgG2a antibody that detects X11β in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). X11β, also known as Mint 2, plays a crucial role in the regulation of β-Amyloid precursor protein (β-APP) processing, which is significant in the context of Alzheimer′s disease. X11β is primarily located in the cytoplasm and interacts with β-APP via phosphotyrosine binding (PTB) domain, effectively modulating the internalization and secretion of β-APP. By binding to the YENPTY motif of β-APP, X11β not only reduces the secretion of cellular β-APP but also slows down the processing pathways that lead to the formation of amyloid plaques, a hallmark of Alzheimer′s pathology. X11β′s importance in this context cannot be overstated, as X11β highlights potential therapeutic targets for modulating β-APP processing and offers insights into the molecular mechanisms underlying neurodegeneration. Anti-X11β antibody (E-4) serves as an essential tool for researchers investigating the intricate pathways involved in Alzheimer′s disease and related neurodegenerative disorders.

The preferred X11β antibody is X11β Antibody (B-5): sc-377060.