X11β Antibody (E-4): sc-376510
- X11β Antibody (E-4) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 3-31 at the N-terminus of X11β of human origin
- recommended for detection of X11β of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for X11β Antibody (E-4) for WB applications. These reagents are now offered in bundles with X11β Antibody (E-4) (see ordering information below).
X11β Antibody (E-4) is a mouse monoclonal IgG2a antibody that detects X11β in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). X11β, also known as Mint 2, plays a crucial role in the regulation of β-Amyloid precursor protein (β-APP) processing, which is significant in the context of Alzheimer′s disease. X11β is primarily located in the cytoplasm and interacts with β-APP via phosphotyrosine binding (PTB) domain, effectively modulating the internalization and secretion of β-APP. By binding to the YENPTY motif of β-APP, X11β not only reduces the secretion of cellular β-APP but also slows down the processing pathways that lead to the formation of amyloid plaques, a hallmark of Alzheimer′s pathology. X11β′s importance in this context cannot be overstated, as X11β highlights potential therapeutic targets for modulating β-APP processing and offers insights into the molecular mechanisms underlying neurodegeneration. Anti-X11β antibody (E-4) serves as an essential tool for researchers investigating the intricate pathways involved in Alzheimer′s disease and related neurodegenerative disorders.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
X11β Antibody (E-4) | sc-376510 | 200 µg/ml | $322.00 | |||
X11β Antibody (E-4): m-IgG Fc BP-HRP Bundle | sc-540586 | 200 µg Ab; 10 µg BP | $361.00 | |||
X11β Antibody (E-4): m-IgG2a BP-HRP Bundle | sc-546931 | 200 µg Ab; 10 µg BP | $361.00 | |||
X11β (E-4) Neutralizing Peptide | sc-376510 P | 100 µg/0.5 ml | $69.00 |