X11α Antibody (C-2): sc-137023

X11α Antibody (C-2) is a mouse monoclonal IgG1 antibody that detects X11α in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). X11α is a neuronal transmembrane protein that plays a crucial role in modulating the processing of the β-Amyloid precursor protein (β-APP), which is significantly implicated in Alzheimer′s disease pathology. By binding to the YENPTY motif of β-APP via its phosphotyrosine binding domain, X11α reduces the secretion of cellular β-APP and slows down its processing pathways, thereby influencing amyloid plaque formation. The interaction of X11α with β-APP is vital for understanding the mechanisms underlying Alzheimer′s disease, as X11α may provide insights into potential therapeutic targets for modulating amyloidogenic processes. Additionally, multiple splice variants of X11, including X11α (Mint 1), X11β (Mint 2), and X11γ (Mint 3), have been identified, each potentially contributing to the regulation of β-APP and its associated pathways. Anti-X11α antibody (C-2) is an essential tool for researchers investigating the complex interactions and functions of β-APP and its regulatory proteins in neurodegenerative diseases.

The preferred X11α antibody is X11α Antibody (A-12): sc-137022.