X11α Antibody (B-12): sc-137024
- X11α Antibody (B-12) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 1-265 mapping near the N-terminus of X11α of human origin
- recommended for detection of X11α of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for X11α Antibody (B-12) for WB applications. These reagents are now offered in bundles with X11α Antibody (B-12) (see ordering information below).
X11α Antibody (B-12) is a mouse monoclonal IgG1 antibody that detects X11α in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). X11α, also known as Mint 1, plays a crucial role in the regulation of β-Amyloid precursor protein (β-APP) processing, which is significant in the context of Alzheimer′s disease. X11α is primarily located in the cytoplasm and at the synapses of neurons, where X11α interacts with β-APP via its phosphotyrosine binding (PTB) domain. By binding to the YENPTY motif of β-APP, X11α reduces the secretion of cellular β-APP and slows down its processing pathways, thereby influencing the formation of amyloid plaques that are characteristic of Alzheimer′s pathology. The modulation of β-APP processing by X11α is essential for maintaining neuronal health and function, highlighting the importance of this interaction in neurodegenerative diseases. Anti-X11α antibody (B-12) is an invaluable tool for researchers investigating the molecular mechanisms underlying Alzheimer′s disease and related disorders.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
X11α Antibody (B-12) | sc-137024 | 200 µg/ml | $322.00 | |||
X11α Antibody (B-12): m-IgG Fc BP-HRP Bundle | sc-539918 | 200 µg Ab; 10 µg BP | $361.00 | |||
X11α Antibody (B-12): m-IgG1 BP-HRP Bundle | sc-541786 | 200 µg Ab; 20 µg BP | $361.00 |