WWOX Antibody (A-5): sc-373846
- WWOX Antibody (A-5) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 71-111 within an internal region of WWOX of human origin
- recommended for detection of WWOX of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and canine and bovine
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for WWOX Antibody (A-5) for WB and IHC(P) applications. These reagents are now offered in bundles with WWOX Antibody (A-5) (see ordering information below).
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WWOX Antibody (A-5) is a mouse monoclonal IgG2b antibody that detects WWOX of mouse, rat, and human origins through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). WWOX, or WW domain containing oxidoreductase, plays a crucial role as a candidate tumor suppressor, featuring two WW domains that facilitate protein-protein interactions and a short chain dehydrogenase (SDR) domain that is integral to sex-steroid metabolism. WWOX modulates cellular processes that influence cancer development; alterations in WWOX have been linked to esophageal squamous cell carcinogenesis and the tumorigenicity of breast cancer cell lines such as MDA-MB-435 and T47D. The murine homolog WOX1 is localized in the mitochondria, where WOX1 contains a mitochondrial targeting sequence within the SDR domain, underscoring WOX1′s significance in cellular energy metabolism and apoptosis regulation. WOX1 can physically associate with JNK1, which sequesters WOX1-dependent apoptosis, highlighting the intricate interplay between these proteins in cancer biology. Anti-WWOX antibody (A-5) is an essential tool for researchers investigating the molecular mechanisms underlying tumor suppression and the role of WWOX in various cancers.
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WWOX Antibody (A-5) References:
- WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies. | Aldaz, CM., et al. 2014. Biochim Biophys Acta. 1846: 188-200. PMID: 24932569
- WWOX Phosphorylation, Signaling, and Role in Neurodegeneration. | Liu, CC., et al. 2018. Front Neurosci. 12: 563. PMID: 30158849
- WWOX Tumor Suppressor Gene in Breast Cancer, a Historical Perspective and Future Directions. | Pospiech, K., et al. 2018. Front Oncol. 8: 345. PMID: 30211123
- Decoding the link between WWOX and p53 in aggressive breast cancer. | Abdeen, SK. and Aqeilan, RI. 2019. Cell Cycle. 18: 1177-1186. PMID: 31075076
- WWOX and Its Binding Proteins in Neurodegeneration. | Hsu, CY., et al. 2021. Cells. 10: PMID: 34359949
- WWOX and metabolic regulation in normal and pathological conditions. | Baryła, I., et al. 2022. J Mol Med (Berl). 100: 1691-1702. PMID: 36271927
- WWOX Modulates ROS-Dependent Senescence in Bladder Cancer. | Liu, CW., et al. 2022. Molecules. 27: PMID: 36364214
- LINC01137/miR-186-5p/WWOX: a novel axis identified from WWOX-related RNA interactome in bladder cancer. | Kołat, D., et al. 2023. Front Genet. 14: 1214968. PMID: 37519886
- Mechanistic Investigation of WWOX Function in NF-kB-Induced Skin Inflammation in Psoriasis. | Shin, MJ., et al. 2023. Int J Mol Sci. 25: PMID: 38203337
- WWOX tuning of oleic acid signaling orchestrates immunosuppressive macrophage polarization and sensitizes hepatocellular carcinoma to immunotherapy. | Liu, S., et al. 2024. J Immunother Cancer. 12: PMID: 39500530
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WWOX Antibody (A-5) | sc-373846 | 200 µg/ml | $322.00 | |||
WWOX Antibody (A-5): m-IgG Fc BP-HRP Bundle | sc-540406 | 200 µg Ab; 10 µg BP | $361.00 | |||
WWOX Antibody (A-5): m-IgG2b BP-HRP Bundle | sc-549785 | 200 µg Ab; 10 µg BP | $361.00 | |||
WWOX (A-5) Neutralizing Peptide | sc-373846 P | 100 µg/0.5 ml | $69.00 |