WWC2 Antibody (H-1): sc-515892
- WWC2 Antibody (H-1) is a mouse monoclonal IgG2b κ WWC2 antibody provided at 200 µg/ml
- raised against amino acids 1119-1168 mapping near the C-terminus of WWC2 of human origin
- WWC2 Antibody (H-1) is recommended for detection of WWC2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-WWC2 Antibody (H-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for WWC2 Antibody (H-1) for WB applications. These reagents are now offered in bundles with WWC2 Antibody (H-1) (see ordering information below).
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WWC2 Antibody (H-1) is a mouse monoclonal IgG2b kappa light chain antibody that detects WWC2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). WWC2 Antibody (H-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. WWC2, also known as BOMB (BH-3-only member B), is a significant 1,192 amino acid protein that plays a crucial role in cellular signaling pathways, particularly in the regulation of apoptosis and cell proliferation. WWC2′s structure includes one C2 domain and two WW domains, which are essential for protein-protein interactions, allowing WWC2 to interact with various signaling molecules and modulate their activity. WWC2 exists as seven alternatively spliced isoforms, providing functional diversity that is vital for its role in different cellular contexts. The gene encoding WWC2 is located on human chromosome 4q35.1, a region that is not only rich in genes but also associated with several genetic disorders, highlighting WWC2′s importance in both normal physiology and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
WWC2 Antibody (H-1) References:
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. | Hillier, LW., et al. 2005. Nature. 434: 724-31. PMID: 15815621
- Selective neuronal degeneration in Huntington's disease. | Cowan, CM. and Raymond, LA. 2006. Curr Top Dev Biol. 75: 25-71. PMID: 16984809
- Syndromic craniosynostosis: from history to hydrogen bonds. | Cunningham, ML., et al. 2007. Orthod Craniofac Res. 10: 67-81. PMID: 17552943
- Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia. | Ruiz-Perez, VL., et al. 2007. Development. 134: 2903-12. PMID: 17660199
- Growth hormone analysis and treatment in Ellis-van Creveld syndrome. | Versteegh, FG., et al. 2007. Am J Med Genet A. 143A: 2113-21. PMID: 17702014
- Metabolic phenotype of methylmalonic acidemia in mice and humans: the role of skeletal muscle. | Chandler, RJ., et al. 2007. BMC Med Genet. 8: 64. PMID: 17937813
- Muenke syndrome (FGFR3-related craniosynostosis): expansion of the phenotype and review of the literature. | Doherty, ES., et al. 2007. Am J Med Genet A. 143A: 3204-15. PMID: 18000976
- Neuroprotective effects of synaptic modulation in Huntington's disease R6/2 mice. | Stack, EC., et al. 2007. J Neurosci. 27: 12908-15. PMID: 18032664
- Snail1 is a transcriptional effector of FGFR3 signaling during chondrogenesis and achondroplasias. | de Frutos, CA., et al. 2007. Dev Cell. 13: 872-83. PMID: 18061568
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WWC2 Antibody (H-1) | sc-515892 | 200 µg/ml | $322.00 | |||
WWC2 Antibody (H-1): m-IgGκ BP-HRP Bundle | sc-525271 | 200 µg Ab, 40 µg BP | $361.00 | |||
WWC2 Antibody (H-1): m-IgG2b BP-HRP Bundle | sc-549224 | 200 µg Ab; 10 µg BP | $361.00 | |||
WWC2 Antibody (H-1) AC | sc-515892 AC | 500 µg/ml, 25% agarose | $424.00 | |||
WWC2 Antibody (H-1) HRP | sc-515892 HRP | 200 µg/ml | $322.00 | |||
WWC2 Antibody (H-1) FITC | sc-515892 FITC | 200 µg/ml | $336.00 | |||
WWC2 Antibody (H-1) PE | sc-515892 PE | 200 µg/ml | $349.00 | |||
WWC2 Antibody (H-1) Alexa Fluor® 488 | sc-515892 AF488 | 200 µg/ml | $364.00 | |||
WWC2 Antibody (H-1) Alexa Fluor® 546 | sc-515892 AF546 | 200 µg/ml | $364.00 | |||
WWC2 Antibody (H-1) Alexa Fluor® 594 | sc-515892 AF594 | 200 µg/ml | $364.00 | |||
WWC2 Antibody (H-1) Alexa Fluor® 647 | sc-515892 AF647 | 200 µg/ml | $364.00 | |||
WWC2 Antibody (H-1) Alexa Fluor® 680 | sc-515892 AF680 | 200 µg/ml | $364.00 | |||
WWC2 Antibody (H-1) Alexa Fluor® 790 | sc-515892 AF790 | 200 µg/ml | $364.00 |