WRN Antibody (F-33): sc-101110
- WRN Antibody (F-33) is a mouse monoclonal IgG2a κ provided at 100 µg/ml
- raised against recombinant WRN of human origin
- recommended for detection of WRN of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for WRN Antibody (F-33). This work is in progress.
QUICK LINKS
SEE ALSO...
WRN Antibody (F-33) is a mouse monoclonal IgG2a antibody that detects WRN in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). WRN, or Werner′s syndrome protein, plays a crucial role in maintaining genomic stability by participating in DNA repair processes, particularly in the unwinding of DNA during replication and repair. This function is vital as WRN helps prevent the accumulation of DNA damage, which can lead to age-related diseases and cancer, conditions that are notably prevalent in individuals with Werner′s syndrome. WRN is located in the nucleus, where WRN interacts with various other proteins involved in DNA metabolism, including those responsible for homologous recombination and nucleotide excision repair. Understanding WRN function and interactions is essential for elucidating the mechanisms underlying premature aging and cancer susceptibility, making anti-WRN antibody (F-33) a valuable tool for researchers studying these critical biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
WRN Antibody (F-33) References:
- L-WRN conditioned medium for gastrointestinal epithelial stem cell culture shows replicable batch-to-batch activity levels across multiple research teams. | VanDussen, KL., et al. 2019. Stem Cell Res. 37: 101430. PMID: 30933720
- Repeat expansions confer WRN dependence in microsatellite-unstable cancers. | van Wietmarschen, N., et al. 2020. Nature. 586: 292-298. PMID: 32999459
- WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells. | Datta, A., et al. 2021. Nat Commun. 12: 6561. PMID: 34772932
- Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR. | Zong, D., et al. 2023. Genes Dev. 37: 913-928. PMID: 37932011
- WRN Is a Promising Synthetic Lethal Target for Cancers with Microsatellite Instability (MSI). | Chan, EM., et al. 2023. Cancer Treat Res. 186: 313-328. PMID: 37978143
- Challenges for the Discovery of Non-Covalent WRN Helicase Inhibitors. | Heuser, A., et al. 2024. ChemMedChem. 19: e202300613. PMID: 38334957
- Novel WRN Helicase Inhibitors Selectively Target Microsatellite-Unstable Cancer Cells. | Picco, G., et al. 2024. Cancer Discov. 14: 1457-1475. PMID: 38587317
- WRN inhibition leads to its chromatin-associated degradation via the PIAS4-RNF4-p97/VCP axis. | Rodríguez Pérez, F., et al. 2024. Nat Commun. 15: 6059. PMID: 39025847
- SNORD88B-mediated WRN nucleolar trafficking drives self-renewal in liver cancer initiating cells and hepatocarcinogenesis. | Gu, Y., et al. 2024. Nat Commun. 15: 6730. PMID: 39112443
- Response to Replication Stress and Maintenance of Genome Stability by WRN, the Werner Syndrome Protein. | Orren, DK. and Machwe, A. 2024. Int J Mol Sci. 25: PMID: 39125869
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WRN Antibody (F-33) | sc-101110 | 100 µg/ml | $333.00 |