Wnt-10b Antibody (F-7): sc-518155
- Wnt-10b Antibody (F-7) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 190-212 of Wnt-10b of human origin
- recommended for detection of Wnt-10b of human origin by WB, IP, IF and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Wnt-10b Antibody (F-7) for WB applications. This reagent is now offered in a bundle with Wnt-10b Antibody (F-7) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
Wnt-10b Antibody (F-7) is a mouse monoclonal IgG2b antibody that detects Wnt-10b in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Wnt-10b is a crucial member of the Wnt gene family, known for regulating cellular growth and differentiation. This cysteine-rich secreted glycoprotein is primarily involved in the development of various tissues and organs, particularly in embryonic development and stem cell regulation. Notably, Wnt-10b has been shown to interact with other signaling pathways, including the fibroblast growth factor (FGF) pathway, which is essential for mammary gland development and has implications in tumorigenesis. Wnt-10b′s ability to modulate cell fate decisions and involvement in processes such as myogenesis highlight its importance in both normal physiological functions and pathological conditions, including cancer. Wnt-10b′s expression is tightly regulated, and dysregulation can lead to various developmental disorders and malignancies, making Wnt-10b a critical target for research in developmental biology and cancer therapeutics. Anti-Wnt-10b antibody (F-7) provides a valuable tool for researchers aiming to explore the intricate roles of Wnt signaling in health and disease.
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Wnt-10b Antibody (F-7) References:
- Wnt-10b promotes differentiation of skin epithelial cells in vitro. | Ouji, Y., et al. 2006. Biochem Biophys Res Commun. 342: 28-35. PMID: 16469292
- Wnt-10b secreted from lymphocytes promotes differentiation of skin epithelial cells. | Ouji, Y., et al. 2006. Biochem Biophys Res Commun. 342: 1063-9. PMID: 16510119
- Canonical Wnts, specifically Wnt-10b, show ability to maintain dermal papilla cells. | Ouji, Y., et al. 2013. Biochem Biophys Res Commun. 438: 493-9. PMID: 23916705
- Effects of Wnt-10b on proliferation and differentiation of murine melanoma cells. | Misu, M., et al. 2015. Biochem Biophys Res Commun. 463: 618-23. PMID: 26056007
- Maintenance of Dermal Papilla Cells by Wnt-10b In Vitro. | Ouji, Y. and Yoshikawa, M. 2016. Methods Mol Biol. 1516: 269-277. PMID: 27032939
- Association of Anabolic Effect of Calcitriol with Osteoclast-Derived Wnt 10b Secretion. | Lu, CL., et al. 2018. Nutrients. 10: PMID: 30149605
- Osteoclast-Released Wnt-10b Underlies Cinacalcet Related Bone Improvement in Chronic Kidney Disease. | Zheng, CM., et al. 2019. Int J Mol Sci. 20: PMID: 31181716
- Cyclic Adenosine Monophosphate (cAMP)-Dependent Phosphodiesterase Inhibition Promotes Bone Anabolism Through CD8+ T Cell Wnt-10b Production in Mice. | Roser-Page, S., et al. 2022. JBMR Plus. 6: e10636. PMID: 35866149
- Mathematical modeling of the effects of Wnt-10b on bone metabolism. | Cook, CV., et al. 2022. AIChE J. 68: PMID: 36567819
- Wnt-10b directs hypermorphic development and transformation in mammary glands of male and female mice. | Lane, TF. and Leder, P. 1997. Oncogene. 15: 2133-44. PMID: 9393971
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Wnt-10b Antibody (F-7) | sc-518155 | 200 µg/ml | $322.00 | |||
Wnt-10b Antibody (F-7): m-IgGκ BP-HRP Bundle | sc-542719 | 200 µg Ab; 40 µg BP | $361.00 |