WISP-1 Antibody (C-2): sc-133198

WISP-1 Antibody (C-2) is a mouse monoclonal IgG2b antibody that detects WISP-1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). WISP-1, a member of the CCN family of growth factors, plays a crucial role in various biological processes, including cell proliferation, differentiation, and angiogenesis, making WISP-1 significant in both normal physiology and disease states. WISP-1 is primarily expressed in adult heart, kidney, and spleen tissues, and WISP-1 expression is notably upregulated in cells transformed with the proto-oncogene Wnt-1, as well as in human colon tumors, indicating WISP-1′s potential involvement in tumorigenesis. The structure of WISP-1 includes four conserved cysteine-rich domains, which are essential for WISP-1′s dimerization and functional activity, highlighting the importance of WISP-1′s structural integrity in mediating biological effects. Additionally, WISP-1′s interactions with other proteins in the CCN family, such as WISP-2 and connective tissue growth factor (CTGF), suggest a complex network of signaling pathways that may influence cellular behavior and contribute to pathological conditions. anti-WISP-1 antibody (C-2) is an invaluable tool for researchers investigating the roles of WISP-1 in cancer biology and tissue development.

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WISP-1 Antibody (C-2) References:

1. Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation.  |  Soon, LL., et al. 2003. J Biol Chem. 278: 11465-70. PMID: 12529380
2. Differential expression of the CCN family member WISP-1, WISP-2 and WISP-3 in human colorectal cancer and the prognostic implications.  |  Davies, SR., et al. 2010. Int J Oncol. 36: 1129-36. PMID: 20372786
3. Activation of Notch1 signaling in stromal fibroblasts inhibits melanoma growth by upregulating WISP-1.  |  Shao, H., et al. 2011. Oncogene. 30: 4316-26. PMID: 21516124
4. Apoptosis signal-regulating kinase 1 is involved in WISP-1-promoted cell motility in human oral squamous cell carcinoma cells.  |  Chuang, JY., et al. 2013. PLoS One. 8: e78022. PMID: 24205072
5. Serum levels of WNT1-inducible signaling pathway protein-1 (WISP-1): a noninvasive biomarker of renal fibrosis in subjects with chronic kidney disease.  |  Zhong, X., et al. 2017. Am J Transl Res. 9: 2920-2932. PMID: 28670380
6. Assessment of circulating Wnt1 inducible signalling pathway protein 1 (WISP-1)/CCN4 as a novel biomarker of obesity.  |  Tacke, C., et al. 2018. J Cell Commun Signal. 12: 539-548. PMID: 29129025
7. Osteoblast-secreted WISP-1 promotes adherence of prostate cancer cells to bone via the VCAM-1/integrin α4β1 system.  |  Chang, AC., et al. 2018. Cancer Lett. 426: 47-56. PMID: 29627497
8. Exercise intervention lowers aberrant serum WISP-1 levels with insulin resistance in breast cancer survivors: a randomized controlled trial.  |  Chang, JS., et al. 2020. Sci Rep. 10: 10898. PMID: 32616883
9. The correlation between two potentially antagonistic human adipocytokines, WISP-1 and CTRP1, and their association with insulin resistance.  |  Mirr, M., et al. 2023. Ann Agric Environ Med. 30: 555-560. PMID: 37772534
10. The interplay of cancer-associated fibroblasts and apoptotic cancer cells suppresses lung cancer cell growth through WISP-1-integrin ανβ3-STAT1 signaling pathway.  |  Kim, S., et al. 2025. Cell Commun Signal. 23: 98. PMID: 39966869

The preferred WISP-1 antibody is WISP-1 Antibody (A-9): sc-133126.