Whirlin Antibody (D-5): sc-271939

Whirlin Antibody (D-5) is a mouse monoclonal IgG1 antibody that detects Whirlin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Whirlin is a crucial cytoplasmic protein containing PDZ domains, primarily localized in the cochlear hair cells of the inner ear, where Whirlin plays a vital role in the elongation and maintenance of stereocilia, the mechanosensory organelles essential for hearing. Proper localization of Whirlin ensures effective assembly and function of stereocilia, which are critical for converting sound vibrations into neural signals. Whirlin interacts with various proteins, including Myosin XVa, which transports Whirlin to the tips of stereocilia, facilitating their elongation. Additionally, Whirlin′s interaction with p55 is important for the structural integrity of stereocilia, and mutations in the DFNB31 gene, which encodes Whirlin, can lead to early loss of p55 labeling and result in recessive hearing loss in both rats and humans. Anti-Whirlin antibody (D-5) is an invaluable tool for researchers studying auditory function and the molecular mechanisms underlying hearing loss.

The preferred Whirlin antibody is Whirlin Antibody (G-8): sc-365250.