WDR77 Antibody (A-4): sc-376556

WDR77 Antibody (A-4) is a mouse monoclonal IgG2a antibody that detects WDR77 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). WDR77, also known as MEP50, is a 342 amino acid protein characterized by the presence of five WD-repeats, which are essential for its function in the assembly of U small nuclear ribonucleoproteins (U snRNPs). WDR77 plays a critical role in the regulation of RNA processing and is a key component of a methyltransferase complex that includes protein arginine methyltransferase 5 (PRMT5). The complex is responsible for converting arginine residues in spliceosomal Sm proteins to dimethylarginines, a modification that is crucial for the subsequent targeting of these proteins to the survival of motor neurons (SMN) complex, where they are assembled into ribonucleoprotein core particles. The proper functioning of WDR77 and its associated methyltransferase complex is vital for maintaining cellular homeostasis and regulating gene expression, and dysregulation of this process has been implicated in the development of testicular tumors, highlighting its potential role in carcinogenesis. Anti-WDR77 antibody (A-4) is an invaluable tool for researchers investigating the molecular mechanisms underlying RNA processing and its implications in cancer biology.

The preferred WDR77 antibody is WDR77 Antibody (C-2): sc-376549.