WDR1 Antibody (B-8): sc-393130
- WDR1 Antibody (B-8) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 425-606 mapping at the C-terminus of WDR1 of human origin
- recommended for detection of WDR1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for WDR1 Antibody (B-8) for WB and IHC(P) applications. These reagents are now offered in bundles with WDR1 Antibody (B-8) (see ordering information below).
WDR1 Antibody (B-8) is a mouse monoclonal IgG1 antibody that detects WDR1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). WDR1, also known as AIP1 or NORI-1, is a 606 amino acid protein characterized by the presence of 11 WD repeats, which are motifs that typically form a tertiary propeller structure and play crucial roles in cellular functions such as signal transduction, apoptosis, and transcriptional regulation. WDR1 is primarily localized to the cytoskeleton, where WDR1 is essential for the disassembly of actin filaments, a process vital for maintaining cellular shape and facilitating cell movement. WDR1 achieves this in conjunction with ADF/cofilin family proteins, highlighting WDR1′s importance in actin dynamics and cellular motility. WDR1′s ability to interact with other proteins and mediate the assembly of protein complexes further underscores WDR1′s role in regulating various cellular processes, making WDR1 a significant target for research in cell biology and related fields.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
WDR1 Antibody (B-8) References:
- STAT3-induced WDR1 overexpression promotes breast cancer cell migration. | Lee, JH., et al. 2016. Cell Signal. 28: 1753-60. PMID: 27521604
- Platelet WDR1 suppresses platelet activity and is associated with cardiovascular disease. | Montenont, E., et al. 2016. Blood. 128: 2033-2042. PMID: 27609643
- Wdr1-Dependent Actin Reorganization in Platelet Activation. | Dasgupta, SK., et al. 2016. PLoS One. 11: e0162897. PMID: 27627652
- Functions of actin-interacting protein 1 (AIP1)/WD repeat protein 1 (WDR1) in actin filament dynamics and cytoskeletal regulation. | Ono, S. 2018. Biochem Biophys Res Commun. 506: 315-322. PMID: 29056508
- WDR1-regulated actin dynamics is required for outflow tract and right ventricle development. | Hu, J., et al. 2018. Dev Biol. 438: 124-137. PMID: 29654745
- Hippocampal Wdr1 Deficit Impairs Learning and Memory by Perturbing F-actin Depolymerization in Mice. | Wang, J., et al. 2019. Cereb Cortex. 29: 4194-4207. PMID: 30590446
- WDR1 predicts poor prognosis and promotes cancer progression in hepatocellular carcinoma. | Zheng, L., et al. 2018. Int J Clin Exp Pathol. 11: 5682-5693. PMID: 31949654
- YAP signaling is involved in WDR1-regulated proliferation and migration of non-small-cell lung cancer cells. | An, R., et al. 2022. Exp Biol Med (Maywood). 247: 1619-1629. PMID: 35861209
- The tumor-enriched small molecule gambogic amide suppresses glioma by targeting WDR1-dependent cytoskeleton remodeling. | Qu, J., et al. 2023. Signal Transduct Target Ther. 8: 424. PMID: 37935665
- WDR1 promotes prostate cancer progression through Wnt/β-catenin signaling. | Cheng, J., et al. 2024. Med Oncol. 41: 151. PMID: 38743149
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WDR1 Antibody (B-8) | sc-393130 | 200 µg/ml | $322.00 | |||
WDR1 Antibody (B-8): m-IgG Fc BP-HRP Bundle | sc-538147 | 200 µg Ab; 10 µg BP | $361.00 | |||
WDR1 Antibody (B-8): m-IgGκ BP-HRP Bundle | sc-535707 | 200 µg Ab; 40 µg BP | $361.00 | |||
WDR1 Antibody (B-8): m-IgG1 BP-HRP Bundle | sc-545547 | 200 µg Ab; 20 µg BP | $361.00 |