WDR1 Antibody (B-10): sc-393159
- WDR1 Antibody (B-10) is a mouse monoclonal IgG2a κ WDR1 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 425-606 mapping at the C-terminus of WDR1 of human origin
- WDR1 Antibody (B-10) is recommended for detection of WDR1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-WDR1 Antibody (B-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for WDR1 Antibody (B-10) for WB and IHC(P) applications. These reagents are now offered in bundles with WDR1 Antibody (B-10) (see ordering information below).
WDR1 Antibody (B-10) is a mouse monoclonal IgG2a kappa light chain antibody that detects WDR1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-WDR1 antibody (B-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. WDR1, also known as WD repeat domain 1, consists of 606 amino acids and is characterized by the presence of 11 WD repeats, which are structural motifs that facilitate protein-protein interactions. These WD repeats form a distinctive tertiary propeller structure, allowing WDR1 to play a crucial role in the disassembly of actin filaments in collaboration with ADF/cofilin family proteins. This function is vital for maintaining cellular dynamics and regulating processes such as cell motility and morphology. WDR1 is localized to the cytoskeleton, where WDR1 participates in various cellular functions, including signal transduction and transcriptional regulation, making WDR1 an important player in the orchestration of cellular responses. WDR1′s ability to interact with other proteins and mediate the assembly of protein complexes underscores WDR1′s significance in cellular regulation and highlights WDR1′s potential as a target for therapeutic interventions in diseases where actin dynamics are disrupted.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
WDR1 Antibody (B-10) References:
- Subcellular localization of WD40 repeat 1 protein in PC12 rat pheochromocytoma cells. | Shin, DH., et al. 2004. Neurosci Lett. 367: 399-403. PMID: 15337274
- AIP1/WDR1 supports mitotic cell rounding. | Fujibuchi, T., et al. 2005. Biochem Biophys Res Commun. 327: 268-75. PMID: 15629458
- Monad, a WD40 repeat protein, promotes apoptosis induced by TNF-alpha. | Saeki, M., et al. 2006. Biochem Biophys Res Commun. 342: 568-72. PMID: 16487927
- Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia. | Kile, BT., et al. 2007. Blood. 110: 2371-80. PMID: 17515402
- Critical roles of actin-interacting protein 1 in cytokinesis and chemotactic migration of mammalian cells. | Kato, A., et al. 2008. Biochem J. 414: 261-70. PMID: 18494608
- WDR1 presence in the songbird basilar papilla. | Adler, HJ., et al. 2008. Hear Res. 240: 102-11. PMID: 18514449
- WDR1 expression in the normal and noise-damaged chick vestibule. | Suh, MW., et al. 2007. J Vestib Res. 17: 163-70. PMID: 18525142
- Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers. | Kueh, HY., et al. 2008. J Cell Biol. 182: 341-53. PMID: 18663144
- An order of magnitude faster AIP1-associated actin disruption than nucleation by the Arp2/3 complex in lamellipodia. | Tsuji, T., et al. 2009. PLoS One. 4: e4921. PMID: 19290054
- WDR1 expression in normal and noise-damaged Sprague-Dawley rat cochleae. | Song, JJ., et al. 2013. J Comp Neurol. 521: 1470-81. PMID: 22821633
- WDR1 Promotes Cell Growth and Migration and Contributes to Malignant Phenotypes of Non-small Cell Lung Cancer through ADF/cofilin-mediated Actin Dynamics. | Yuan, B., et al. 2018. Int J Biol Sci. 14: 1067-1080. PMID: 29989053
- Knockout of Wdr1 results in cardiac hypertrophy and impaired cardiac function in adult mouse heart. | Huang, X., et al. 2019. Gene. 697: 40-47. PMID: 30794912
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WDR1 Antibody (B-10) | sc-393159 | 200 µg/ml | $322.00 | |||
WDR1 Antibody (B-10): m-IgG Fc BP-HRP Bundle | sc-530375 | 200 µg Ab; 10 µg BP | $361.00 | |||
WDR1 Antibody (B-10): m-IgGκ BP-HRP Bundle | sc-523829 | 200 µg Ab, 40 µg BP | $361.00 | |||
WDR1 Antibody (B-10): m-IgG2a BP-HRP Bundle | sc-547489 | 200 µg Ab; 10 µg BP | $361.00 | |||
WDR1 Antibody (B-10) AC | sc-393159 AC | 500 µg/ml, 25% agarose | $424.00 | |||
WDR1 Antibody (B-10) HRP | sc-393159 HRP | 200 µg/ml | $322.00 | |||
WDR1 Antibody (B-10) FITC | sc-393159 FITC | 200 µg/ml | $336.00 | |||
WDR1 Antibody (B-10) PE | sc-393159 PE | 200 µg/ml | $349.00 | |||
WDR1 Antibody (B-10) Alexa Fluor® 488 | sc-393159 AF488 | 200 µg/ml | $364.00 | |||
WDR1 Antibody (B-10) Alexa Fluor® 546 | sc-393159 AF546 | 200 µg/ml | $364.00 | |||
WDR1 Antibody (B-10) Alexa Fluor® 594 | sc-393159 AF594 | 200 µg/ml | $364.00 | |||
WDR1 Antibody (B-10) Alexa Fluor® 647 | sc-393159 AF647 | 200 µg/ml | $364.00 | |||
WDR1 Antibody (B-10) Alexa Fluor® 680 | sc-393159 AF680 | 200 µg/ml | $364.00 | |||
WDR1 Antibody (B-10) Alexa Fluor® 790 | sc-393159 AF790 | 200 µg/ml | $364.00 |