WC1 Antibody (CC115): sc-101843

WC1 Antibody (CC115) is a mouse monoclonal IgG2a kappa light chain antibody that detects WC1 protein of ovine and caprine origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). WC1 (CC115) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. WC1, a member of the scavenger receptor cysteine-rich (SRCR) family, is a transmembrane glycoprotein uniquely expressed on γδ T cells, which are a significant subset of circulating lymphocytes. These γδ T cells, characterized by WC1 expression, are functionally distinct from αβ T cells and play crucial roles in immune responses. WC1 interacts with various ligands, which can modulate γδ T cell activation and proliferation, thereby influencing overall immune response. Notably, WC1 isoforms WC1.1, WC1.2, and WC1.3 are expressed on different subpopulations of γδ T cells, each contributing uniquely to immune regulation. Conserved signaling motifs in WC1′s cytoplasmic tail suggest a role as an accessory molecule that enhances cellular activation and induces cell cycle arrest, ultimately affecting cell fate through pathways that increase cellular ceramide levels. This multifaceted role of WC1 underscores its importance in the immune system, making anti-WC1 antibody (CC115) an essential tool for researchers studying γδ T cell biology and immune modulation.

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WC1 Antibody (CC115) References:

1. Ligation of the WC1 receptor induces gamma delta T cell growth arrest through fumonisin B1-sensitive increases in cellular ceramide.  |  Kirkham, PA., et al. 2000. J Immunol. 165: 3564-70. PMID: 11034356
2. In vitro responsiveness of gammadelta T cells from Mycobacterium bovis-infected cattle to mycobacterial antigens: predominant involvement of WC1(+) cells.  |  Smyth, AJ., et al. 2001. Infect Immun. 69: 89-96. PMID: 11119493
3. IFN gamma and IL-4 production by CD4, CD8 and WC1 gamma delta TCR(+) T cells from cattle lymph nodes and blood.  |  Sopp, P. and Howard, CJ. 2001. Vet Immunol Immunopathol. 81: 85-96. PMID: 11498249
4. Scavenger receptor cysteine-rich domains 9 and 11 of WC1 are receptors for the WC1 counter receptor.  |  Ahn, JS., et al. 2002. J Leukoc Biol. 72: 382-90. PMID: 12149430
5. Gammadelta T cell function varies with the expressed WC1 coreceptor.  |  Rogers, AN., et al. 2005. J Immunol. 174: 3386-93. PMID: 15749871
6. Advanced granulomatous lesions in Mycobacterium bovis-infected cattle are associated with increased expression of type I procollagen, gammadelta (WC1+) T cells and CD 68+ cells.  |  Wangoo, A., et al. 2005. J Comp Pathol. 133: 223-34. PMID: 16154140
7. Differential TCR gene usage between WC1- and WC1+ ruminant gammadelta T cell subpopulations including those responding to bacterial antigen.  |  Blumerman, SL., et al. 2006. Immunogenetics. 58: 680-92. PMID: 16799810
8. Characterization of WC1 co-receptors on functionally distinct subpopulations of ruminant gamma delta T cells.  |  Rogers, AN., et al. 2006. Cell Immunol. 239: 151-61. PMID: 16828467
9. Comparative gene expression by WC1+ gammadelta and CD4+ alphabeta T lymphocytes, which respond to Anaplasma marginale, demonstrates higher expression of chemokines and other myeloid cell-associated genes by WC1+ gammadelta T cells.  |  Lahmers, KK., et al. 2006. J Leukoc Biol. 80: 939-52. PMID: 17005908

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-WC1 Antibody (CC115) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-WC1 Antibody (CC115) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

WC1 Antibody (CC115) Specifications

Alternate Product Name: WC1

Product Clone Name: CC115

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids:

Epitope Target: WC1

Epitope Species: bovine

Product Reactivity/Detection: WC1

Species Reactivity/Detection: ovine, caprine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for WC1 Antibody (CC115): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin