WAVE1 Antibody (B-8): sc-271506
- WAVE1 Antibody (B-8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 467-499 near the C-terminus of WAVE1 of human origin
- recommended for detection of WAVE1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including bovine
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for WAVE1 Antibody (B-8). This work is in progress.
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WAVE1 Antibody (B-8) is a mouse monoclonal IgG1 antibody that detects WAVE1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). WAVE1, also known as SCAR (suppressor of cAR), plays a crucial role in actin polymerization and cytoskeletal dynamics, which are essential for various cellular processes including cell motility, shape changes, and signal transduction. WAVE1 is primarily expressed in the brain, where WAVE1 is involved in the regulation of membrane ruffling and the formation of actin filament clusters in response to GTP binding, thereby facilitating the activation of the Arp2/3 complex. The interaction of WAVE1 with the Arp2/3 complex is vital for promoting the nucleation of new actin filaments, which is critical for maintaining cellular architecture and enabling dynamic responses to environmental cues. Additionally, WAVE1 forms multiprotein complexes that link receptor kinases to the actin cytoskeleton, thereby playing a significant role in transducing signals that influence cell shape, function, and motility. anti-WAVE1 antibody (B-8) is an invaluable tool for researchers studying the intricate mechanisms of cytoskeletal organization and its implications in various physiological and pathological processes.
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WAVE1 Antibody (B-8) References:
- CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. | Kawano, Y., et al. 2005. Mol Cell Biol. 25: 9920-35. PMID: 16260607
- Superovulatory response of ovarian follicles of Wave 1 versus Wave 2 in heifers. | Adams, GP., et al. 1994. Theriogenology. 42: 1103-13. PMID: 16727614
- WAVE1 and regulation of actin nucleation in myelination. | Sloane, JA. and Vartanian, TK. 2007. Neuroscientist. 13: 486-91. PMID: 17901257
- High level of WAVE1 expression is associated with tumor aggressiveness and unfavorable prognosis of epithelial ovarian cancer. | Zhang, J., et al. 2012. Gynecol Oncol. 127: 223-30. PMID: 22721732
- A novel role for WAVE1 in controlling actin network growth rate and architecture. | Sweeney, MO., et al. 2015. Mol Biol Cell. 26: 495-505. PMID: 25473116
- APP intracellular domain-WAVE1 pathway reduces amyloid-β production. | Ceglia, I., et al. 2015. Nat Med. 21: 1054-9. PMID: 26280122
- Cyclosporine A protects podocytes by regulating WAVE1 phosphorylation. | Li, X., et al. 2015. Sci Rep. 5: 17694. PMID: 26634693
- The Association Between WAVE1 and -3 and the ARP2/3 Complex in PC 3 Cells. | Weeks, HP., et al. 2016. Anticancer Res. 36: 1135-42. PMID: 26977009
- WAVE1 in neurons expressing the D1 dopamine receptor regulates cellular and behavioral actions of cocaine. | Ceglia, I., et al. 2017. Proc Natl Acad Sci U S A. 114: 1395-1400. PMID: 28115704
- WAVE1 and WAVE2 have distinct and overlapping roles in controlling actin assembly at the leading edge. | Tang, Q., et al. 2020. Mol Biol Cell. 31: 2168-2178. PMID: 32697617
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WAVE1 Antibody (B-8) | sc-271506 | 200 µg/ml | $322.00 | |||
WAVE1 (B-8) Neutralizing Peptide | sc-271506 P | 100 µg/0.5 ml | $69.00 |