von Willebrand Factor/VWF Antibody (G-11): sc-271409
- von Willebrand Factor/VWF Antibody (G-11) is a mouse monoclonal IgG1, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 2514-2813 mapping at the C-terminus of VWF (Von Willebrand factor) of human origin
- recommended for detection of VWF of human origin by WB, IP, IF, IHC(P) and ELISA
- See von Willebrand Factor/VWF (C-12): sc-365712 for von Willebrand Factor/VWF antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for von Willebrand Factor/VWF Antibody (G-11) for WB and IHC(P) applications. This reagent is now offered in a bundle with von Willebrand Factor/VWF Antibody (G-11) (see ordering information below).
QUICK LINKS
SEE ALSO...
VWF Antibody (G-11) is a mouse monoclonal IgG1 antibody engineered to recognize the von Willebrand factor (VWF) protein of human origin, targeting amino acids 2514-2813 located at the C-terminus of VWF. VWF monoclonal antibody (G-11) is validated for multiple applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA), making this a versatile tool for both research and diagnostic purposes. VWF is a crucial multimeric glycoprotein involved in hemostasis, synthesized primarily in endothelial cells and megakaryocytes, and stored in Weibel-Palade bodies and platelet alpha granules. Upon vascular injury, VWF is rapidly secreted into the plasma where VWF mediates platelet adhesion and aggregation by interacting with glycoprotein Ib (GPIb) receptors on platelets and binding to collagen in the subendothelial matrix, thereby initiating the clotting cascade. Additionally, VWF serves as a carrier for Factor VIII, protecting Factor VIII from proteolytic degradation and ensuring availability as a vital cofactor in the coagulation process. The C-terminal region targeted by anti-VWF antibody (G-11) is essential for interaction with ADAMTS13, a metalloprotease responsible for cleaving VWF multimers to regulate size and activity, thus preventing excessive platelet aggregation and maintaining hemostatic balance. By specifically binding to this region, VWF (G-11) antibody facilitates the study of VWF′s interactions with these critical proteins, enabling detailed analysis of molecular mechanisms underlying blood coagulation and pathophysiology of von Willebrand disease. Whether employed in basic research to elucidate structural and functional dynamics of VWF or in clinical diagnostics to assess VWF levels and interactions in patient samples, VWF monoclonal antibody (G-11) provides reliable and precise detection, supporting advancements in vascular biology, coagulation research, and development of therapeutic strategies for managing bleeding disorders.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
von Willebrand Factor/VWF Antibody (G-11) | sc-271409 | 200 µg/ml | $316.00 | |||
von Willebrand Factor/VWF Antibody (G-11): m-IgG Fc BP-HRP Bundle | sc-540236 | 200 µg Ab; 10 µg BP | $354.00 |