VWA8 Antibody (E-9): sc-514470
- VWA8 Antibody (E-9) is a mouse monoclonal IgG2b κ VWA8 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1787-1809 at the C-terminus of VWA8 of human origin
- VWA8 Antibody (E-9) is recommended for detection of VWA8 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-VWA8 Antibody (E-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for VWA8 Antibody (E-9) for WB applications. These reagents are now offered in bundles with VWA8 Antibody (E-9) (see ordering information below).
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VWA8 Antibody (E-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects VWA8 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). VWA8 (E-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. VWA8, also known as von Willebrand factor A domain containing 8 or KIAA0564, is a secreted protein consisting of 1,905 amino acids and features a von Willebrand factor A (VWFA) domain, which is critical for cell adhesion and signaling functions. VWA8 plays a significant role in various biological processes, including cell migration regulation and tissue repair, making VWA8 essential for maintaining normal physiological functions. VWA8 gene is located on human chromosome 13q14.11 and mouse chromosome 14 D3, which is notable as chromosome 13 harbors key tumor suppressor genes such as BRCA2 and RB1, both implicated in cancer development. Understanding VWA8 interactions and functions can provide insights into potential roles in tumor biology and other diseases, highlighting VWA8′s importance in both health and disease contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
VWA8 Antibody (E-9) References:
- The DNA sequence and analysis of human chromosome 13. | Dunham, A., et al. 2004. Nature. 428: 522-8. PMID: 15057823
- A new gene for Tourette's syndrome: a window into causal mechanisms? | Grados, MA. and Walkup, JT. 2006. Trends Genet. 22: 291-3. PMID: 16678301
- RB and cell cycle progression. | Giacinti, C. and Giordano, A. 2006. Oncogene. 25: 5220-7. PMID: 16936740
- Examination of the SLITRK1 gene in Caucasian patients with Tourette syndrome. | Deng, H., et al. 2006. Acta Neurol Scand. 114: 400-2. PMID: 17083340
- Non-disjunction of chromosome 13. | Bugge, M., et al. 2007. Hum Mol Genet. 16: 2004-10. PMID: 17584770
- Variable expressivity in Patau syndrome is not all related to trisomy 13 mosaicism. | Hsu, HF. and Hou, JW. 2007. Am J Med Genet A. 143A: 1739-48. PMID: 17603803
- The origin of trisomy 13. | Hall, HE., et al. 2007. Am J Med Genet A. 143A: 2242-8. PMID: 17853475
- Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture. | Hassler, M., et al. 2007. Mol Cell. 28: 371-85. PMID: 17996702
- BRCA2: a universal recombinase regulator. | Thorslund, T. and West, SC. 2007. Oncogene. 26: 7720-30. PMID: 18066084
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VWA8 Antibody (E-9) | sc-514470 | 200 µg/ml | $316.00 | |||
VWA8 Antibody (E-9): m-IgG Fc BP-HRP Bundle | sc-531139 | 200 µg Ab; 10 µg BP | $354.00 | |||
VWA8 Antibody (E-9): m-IgGκ BP-HRP Bundle | sc-524739 | 200 µg Ab, 40 µg BP | $354.00 | |||
VWA8 Antibody (E-9): m-IgG2b BP-HRP Bundle | sc-550261 | 200 µg Ab; 10 µg BP | $354.00 | |||
VWA8 Antibody (E-9) AC | sc-514470 AC | 500 µg/ml, 25% agarose | $416.00 | |||
VWA8 Antibody (E-9) HRP | sc-514470 HRP | 200 µg/ml | $316.00 | |||
VWA8 Antibody (E-9) FITC | sc-514470 FITC | 200 µg/ml | $330.00 | |||
VWA8 Antibody (E-9) PE | sc-514470 PE | 200 µg/ml | $343.00 | |||
VWA8 Antibody (E-9) Alexa Fluor® 488 | sc-514470 AF488 | 200 µg/ml | $357.00 | |||
VWA8 Antibody (E-9) Alexa Fluor® 546 | sc-514470 AF546 | 200 µg/ml | $357.00 | |||
VWA8 Antibody (E-9) Alexa Fluor® 594 | sc-514470 AF594 | 200 µg/ml | $357.00 | |||
VWA8 Antibody (E-9) Alexa Fluor® 647 | sc-514470 AF647 | 200 µg/ml | $357.00 | |||
VWA8 Antibody (E-9) Alexa Fluor® 680 | sc-514470 AF680 | 200 µg/ml | $357.00 | |||
VWA8 Antibody (E-9) Alexa Fluor® 790 | sc-514470 AF790 | 200 µg/ml | $357.00 | |||
VWA8 (E-9) Neutralizing Peptide | sc-514470 P | 100 µg/0.5 ml | $68.00 |