VRL-1 Antibody (B-9): sc-514848
- VRL-1 Antibody (B-9) is a mouse monoclonal IgG1 κ VRL-1 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-105 mapping at the N-terminus of VRL-1 of human origin
- VRL-1 Antibody (B-9) is recommended for detection of VRL-1 of human origin by WB, IP, IF and ELISA
- Anti-VRL-1 Antibody (B-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for VRL-1 Antibody (B-9) for WB applications. These reagents are now offered in bundles with VRL-1 Antibody (B-9) (see ordering information below).
QUICK LINKS
VRL-1 Antibody (B-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects VRL-1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). VRL-1 (B-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. VRL-1, also known as Vanilloid Receptor-Like 1 or Transient Receptor Potential Cation Channel Subfamily V Member 2, plays a crucial role in the sensory perception of extreme temperatures, being activated by heat exceeding 52 degrees Celsius. VRL-1 is predominantly expressed in both neuronal and non-neuronal cells, contributing to the body′s ability to detect and respond to potentially harmful thermal stimuli. VRL-1′s importance lies in its involvement in nociception, the sensory process that allows the body to perceive pain, particularly in response to noxious heat. Understanding VRL-1′s function is vital for developing therapeutic strategies for pain management and for studying conditions related to temperature sensitivity.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
VRL-1 Antibody (B-9) References:
- A capsaicin-receptor homologue with a high threshold for noxious heat. | Caterina, MJ., et al. 1999. Nature. 398: 436-41. PMID: 10201375
- From worm to man: three subfamilies of TRP channels. | Harteneck, C., et al. 2000. Trends Neurosci. 23: 159-66. PMID: 10717675
- Transient receptor potential channels as molecular substrates of receptor-mediated cation entry. | Hofmann, T., et al. 2000. J Mol Med (Berl). 78: 14-25. PMID: 10759026
- Vanilloid receptor homologue, VRL1, is expressed by both A- and C-fiber sensory neurons. | Ma, QP. 2001. Neuroreport. 12: 3693-5. PMID: 11726776
- Identification of a cold receptor reveals a general role for TRP channels in thermosensation. | McKemy, DD., et al. 2002. Nature. 416: 52-8. PMID: 11882888
- A TRP channel that senses cold stimuli and menthol. | Peier, AM., et al. 2002. Cell. 108: 705-15. PMID: 11893340
- Heat-evoked activation of the ion channel, TRPV4. | Güler, AD., et al. 2002. J Neurosci. 22: 6408-14. PMID: 12151520
- Dual expression of mouse and rat VRL-1 in the dorsal root ganglion derived cell line F-11 and biochemical analysis of VRL-1 after heterologous expression. | Jahnel, R., et al. 2003. Eur J Biochem. 270: 4264-71. PMID: 14622291
- Role of vanilloid receptors in the capsaicin-mediated induction of iNOS in PC12 cells. | Qiao, S., et al. 2004. Neurochem Res. 29: 687-93. PMID: 15098930
- Vanilloid receptor like 1 (VRL1) immunoreactivity in mammalian retina: colocalization with somatostatin and purinergic P2X1 receptors. | Yazulla, S. and Studholme, KM. 2004. J Comp Neurol. 474: 407-18. PMID: 15174083
- N-terminal signals in the SNX-BAR paralogs Vps5 and Vin1 guide endosomal coat complex formation. | Shortill, SP., et al. 2024. Mol Biol Cell. 35: ar76. PMID: 38598303
- A novel capacitative calcium entry channel expressed in excitable cells. | Philipp, S., et al. 1998. EMBO J. 17: 4274-82. PMID: 9687496
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VRL-1 Antibody (B-9) | sc-514848 | 200 µg/ml | $316.00 | |||
VRL-1 Antibody (B-9): m-IgG Fc BP-HRP Bundle | sc-531233 | 200 µg Ab; 10 µg BP | $354.00 | |||
VRL-1 Antibody (B-9): m-IgGκ BP-HRP Bundle | sc-524863 | 200 µg Ab, 40 µg BP | $354.00 | |||
VRL-1 Antibody (B-9): m-IgG1 BP-HRP Bundle | sc-544445 | 200 µg Ab; 20 µg BP | $354.00 | |||
VRL-1 Antibody (B-9) AC | sc-514848 AC | 500 µg/ml, 25% agarose | $416.00 | |||
VRL-1 Antibody (B-9) HRP | sc-514848 HRP | 200 µg/ml | $316.00 | |||
VRL-1 Antibody (B-9) FITC | sc-514848 FITC | 200 µg/ml | $330.00 | |||
VRL-1 Antibody (B-9) PE | sc-514848 PE | 200 µg/ml | $343.00 | |||
VRL-1 Antibody (B-9) Alexa Fluor® 488 | sc-514848 AF488 | 200 µg/ml | $357.00 | |||
VRL-1 Antibody (B-9) Alexa Fluor® 546 | sc-514848 AF546 | 200 µg/ml | $357.00 | |||
VRL-1 Antibody (B-9) Alexa Fluor® 594 | sc-514848 AF594 | 200 µg/ml | $357.00 | |||
VRL-1 Antibody (B-9) Alexa Fluor® 647 | sc-514848 AF647 | 200 µg/ml | $357.00 | |||
VRL-1 Antibody (B-9) Alexa Fluor® 680 | sc-514848 AF680 | 200 µg/ml | $357.00 | |||
VRL-1 Antibody (B-9) Alexa Fluor® 790 | sc-514848 AF790 | 200 µg/ml | $357.00 |