VRL-1 Inhibitors
The chemical class of VRL-1 inhibitors includes a diverse array of compounds that influence the activity of the VRL-1 (TRPV2) ion channel, primarily through indirect pathways. These inhibitors function by modulating various cellular mechanisms and signaling pathways, thereby affecting the TRPV2 channel. The class comprises chemicals like Tranilast, which directly inhibits TRPV2 by decreasing its calcium permeability. Other members of this class, such as Ranolazine, modulate calcium homeostasis and receptor-operated calcium channels, indirectly influencing TRPV2 activity.
Further illustrating the diversity within this class are Pyr3 and ML204, selective inhibitors of TRPC3 and TRPC4 channels, respectively, which influence TRPV2 through their roles in calcium signaling. Xestospongin C, targeting the IP3 receptor, and Nifedipine, a blocker of L-type calcium channels, showcase the interplay between different calcium-related pathways and TRPV2 inhibition. Mibefradil and La3+ provide additional examples, targeting T-type calcium channels and various calcium channels, respectively, thereby affecting TRPV2 activity. Flufenamic Acid and Verapamil, while primarily known for their roles as an anti-inflammatory and a calcium channel blocker, respectively, demonstrate the broad-spectrum impact on ion channels and calcium signaling that can lead to the indirect inhibition of TRPV2. This chemical class underscores the complexity of targeting ion channels like TRPV2, highlighting the interconnected nature of cellular signaling pathways and the intricate balance of ion channel regulation in the cellular environment.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tranilast | 53902-12-8 | sc-200389 sc-200389A sc-200389B sc-200389C | 10 mg 50 mg 1 g 5 g | $31.00 $103.00 $283.00 $978.00 | 2 | |
Tranilast is known to inhibit TRPV2 channel activity directly. It achieves this by binding to the channel, leading to a decrease in the channel's permeability to calcium ions, thereby inhibiting its function. | ||||||
Ranolazine | 95635-55-5 | sc-212769 | 1 g | $109.00 | 3 | |
Ranolazine, primarily used for angina, inhibits late sodium currents in cardiac cells. Its inhibition of sodium currents can indirectly modulate calcium homeostasis, potentially inhibiting TRPV2 activity, which is sensitive to intracellular calcium levels. | ||||||
Pyr3 | 1160514-60-2 | sc-301624 sc-301624A sc-301624B | 5 mg 10 mg 25 mg | $151.00 $260.00 $520.00 | ||
Pyr3 is a potent and selective inhibitor of TRPC3 channels. Its inhibition of TRPC3 channels can modulate calcium signaling in the cell, indirectly inhibiting TRPV2 activity. | ||||||
4-Methyl-2-(1-piperidinyl)-quinoline | 5465-86-1 | sc-483337 | 25 mg | $430.00 | ||
ML204 is a novel selective inhibitor of TRPC4 channels. By inhibiting TRPC4, ML204 can influence the overall calcium signaling pathway, potentially inhibiting the activity of TRPV2. | ||||||
Xestospongin C | 88903-69-9 | sc-201505 | 50 µg | $510.00 | 14 | |
Xestospongin C is an inhibitor of the IP3 receptor, which plays a crucial role in calcium release from intracellular stores. By inhibiting this receptor, it can modulate calcium signaling, thereby potentially inhibiting TRPV2 activity. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine, a calcium channel blocker, primarily inhibits L-type calcium channels. Its modulation of calcium influx can indirectly inhibit TRPV2 function due to the interconnectedness of calcium signaling pathways. | ||||||
Flufenamic acid | 530-78-9 | sc-205699 sc-205699A sc-205699B sc-205699C | 10 g 50 g 100 g 250 g | $27.00 $79.00 $154.00 $309.00 | 1 | |
Flufenamic Acid, a nonsteroidal anti-inflammatory drug, can inhibit various ion channels. Its modulation of ion channel activity can influence cellular signaling pathways, thereby indirectly inhibiting TRPV2. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil, another calcium channel blocker, primarily affects L-type calcium channels. Its inhibition of these channels can lead to altered calcium signaling in cells, potentially inhibiting TRPV2 activity indirectly. | ||||||