VPS41 Antibody (D-12): sc-377118
- VPS41 Antibody (D-12) is a mouse monoclonal IgG1 κ VPS41 antibody, cited in 16 publications, provided at 200 µg/ml
- raised against amino acids 301-600 mapping within an internal region of VPS41 of human origin
- VPS41 Antibody (D-12) is recommended for detection of VPS41 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including bovine
- Anti-VPS41 Antibody (D-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for VPS41 Antibody (D-12) for WB and IHC(P) applications. These reagents are now offered in bundles with VPS41 Antibody (D-12) (see ordering information below).
VPS41 Antibody (D-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects VPS41 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). VPS41 Antibody (D-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. VPS41, or vacuolar protein sorting 41, is a crucial protein consisting of 854 amino acids that plays a significant role in protein trafficking to the vacuole, which is essential for maintaining cellular homeostasis. VPS41 contains one clathrin repeat and one RING-type zinc finger, contributing to transport vesicle formation and fusion from the Golgi apparatus. VPS41 exists in two alternatively spliced isoforms, short and long, allowing for functional diversity in cellular processes. VPS41 is located on human chromosome 7, a region associated with various genetic disorders, including Osteogenesis imperfecta and Williams-Beuren syndrome, highlighting VPS41′s importance in cellular health and potential implications in disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
VPS41 Antibody (D-12) References:
- Formation of AP-3 transport intermediates requires Vps41 function. | Rehling, P., et al. 1999. Nat Cell Biol. 1: 346-53. PMID: 10559961
- hVPS41 is expressed in multiple isoforms and can associate with vesicles through a RING-H2 finger motif. | McVey Ward, D., et al. 2001. Exp Cell Res. 267: 126-34. PMID: 11412045
- The vacuolar V1/V0-ATPase is involved in the release of the HOPS subunit Vps41 from vacuoles, vacuole fragmentation and fusion. | Takeda, K., et al. 2008. FEBS Lett. 582: 1558-63. PMID: 18405665
- Efficient termination of vacuolar Rab GTPase signaling requires coordinated action by a GAP and a protein kinase. | Brett, CL., et al. 2008. J Cell Biol. 182: 1141-51. PMID: 18809726
- Characterization of VPS41, a gene required for vacuolar trafficking and high-affinity iron transport in yeast. | Radisky, DC., et al. 1997. Proc Natl Acad Sci U S A. 94: 5662-6. PMID: 9159129
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VPS41 Antibody (D-12) | sc-377118 | 200 µg/ml | $322.00 | |||
VPS41 Antibody (D-12): m-IgG Fc BP-HRP Bundle | sc-529977 | 200 µg Ab; 10 µg BP | $361.00 | |||
VPS41 Antibody (D-12): m-IgGκ BP-HRP Bundle | sc-523195 | 200 µg Ab, 40 µg BP | $361.00 | |||
VPS41 Antibody (D-12): m-IgG1 BP-HRP Bundle | sc-543799 | 200 µg Ab; 20 µg BP | $361.00 | |||
VPS41 Antibody (D-12) AC | sc-377118 AC | 500 µg/ml, 25% agarose | $424.00 | |||
VPS41 Antibody (D-12) HRP | sc-377118 HRP | 200 µg/ml | $322.00 | |||
VPS41 Antibody (D-12) FITC | sc-377118 FITC | 200 µg/ml | $336.00 | |||
VPS41 Antibody (D-12) PE | sc-377118 PE | 200 µg/ml | $349.00 | |||
VPS41 Antibody (D-12) Alexa Fluor® 488 | sc-377118 AF488 | 200 µg/ml | $364.00 | |||
VPS41 Antibody (D-12) Alexa Fluor® 546 | sc-377118 AF546 | 200 µg/ml | $364.00 | |||
VPS41 Antibody (D-12) Alexa Fluor® 594 | sc-377118 AF594 | 200 µg/ml | $364.00 | |||
VPS41 Antibody (D-12) Alexa Fluor® 647 | sc-377118 AF647 | 200 µg/ml | $364.00 | |||
VPS41 Antibody (D-12) Alexa Fluor® 680 | sc-377118 AF680 | 200 µg/ml | $364.00 | |||
VPS41 Antibody (D-12) Alexa Fluor® 790 | sc-377118 AF790 | 200 µg/ml | $364.00 |