VMAT 2 Antibody (H-12): sc-374079
- VMAT 2 Antibody (H-12) is a mouse monoclonal IgG1 κ VMAT 2 antibody, cited in 8 publications, provided at 200 µg/ml
- raised against amino acids 44-133 mapping near the N-terminus of VMAT 2 of human origin
- VMAT 2 Antibody (H-12) is recommended for detection of VMAT 2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-VMAT 2 Antibody (H-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of VMAT 2 (H-12): sc-374079.
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for VMAT 2 Antibody (H-12) for WB and IHC(P) applications. These reagents are now offered in bundles with VMAT 2 Antibody (H-12) (see ordering information below).
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VMAT 2 Antibody (H-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects VMAT 2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). VMAT 2 (H-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. VMAT 2 protein plays a crucial role in neurotransmission by facilitating the packaging of monoamines, such as dopamine, serotonin, and norepinephrine, into synaptic vesicles, which is essential for the regulated release of these neurotransmitters during neuronal signaling. This process is vital for proper communication between neurons and is implicated in various neurological disorders when dysregulated. Structurally, VMAT 2 is characterized by twelve transmembrane domains, which are essential for its function as a vesicular transporter, and shares weak homology with a class of bacterial antibiotic resistance proteins, highlighting evolutionary significance. The active transport mechanism of VMAT 2 is ATP- and proton-dependent, underscoring the energy requirements for neurotransmitter packaging and release.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
VMAT 2 Antibody (H-12) References:
- A New VMAT-2 Inhibitor NBI-641449 in the Treatment of Huntington Disease. | Chen, S., et al. 2015. CNS Neurosci Ther. 21: 662-71. PMID: 26122704
- A new class of VMAT-2 inhibitors for tardive dyskinesia. | Correll, CU. and Carbon, M. 2017. Lancet Psychiatry. 4: 574-575. PMID: 28668670
- Treatment of tardive dyskinesia with VMAT-2 inhibitors: a systematic review and meta-analysis of randomized controlled trials. | Solmi, M., et al. 2018. Drug Des Devel Ther. 12: 1215-1238. PMID: 29795977
- Meta-analysis and systematic review of vesicular monoamine transporter (VMAT-2) inhibitors in schizophrenia and psychosis. | Connolly, A., et al. 2024. Psychopharmacology (Berl). 241: 225-241. PMID: 38238580
- Dissemination of VMAT-2 Inhibitors: A New Class Drug for Tardive Dyskinesia and Huntington Disease. | Ma, E., et al. 2025. Neurol Clin Pract. 15: e200392. PMID: 39399570
- Biochemistry and molecular biology of the vesicular monoamine transporter from chromaffin granules. | Henry, JP., et al. 1994. J Exp Biol. 196: 251-62. PMID: 7823026
- Molecular cloning of a putative vesicular transporter for acetylcholine. | Roghani, A., et al. 1994. Proc Natl Acad Sci U S A. 91: 10620-4. PMID: 7938002
- Acetylcholine active transport by rat brain synaptic vesicles. | Haigh, JR., et al. 1994. Neuroreport. 5: 773-6. PMID: 8018848
- The pharmacological profile of the vesicular monoamine transporter resembles that of multidrug transporters. | Yelin, R. and Schuldiner, S. 1995. FEBS Lett. 377: 201-7. PMID: 8543051
- Active transport of acetylcholine by the human vesicular acetylcholine transporter. | Varoqui, H. and Erickson, JD. 1996. J Biol Chem. 271: 27229-32. PMID: 8910293
- Vesicular neurotransmitter transporters. Potential sites for the regulation of synaptic function. | Varoqui, H. and Erickson, JD. 1997. Mol Neurobiol. 15: 165-91. PMID: 9396009
- Vesicular neurotransmitter transport and the presynaptic regulation of quantal size. | Reimer, RJ., et al. 1998. Curr Opin Neurobiol. 8: 405-12. PMID: 9687352
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VMAT 2 Antibody (H-12) | sc-374079 | 200 µg/ml | $316.00 | |||
VMAT 2 Antibody (H-12): m-IgG Fc BP-HRP Bundle | sc-529653 | 200 µg Ab; 10 µg BP | $354.00 | |||
VMAT 2 Antibody (H-12): m-IgGκ BP-HRP Bundle | sc-522611 | 200 µg Ab, 40 µg BP | $354.00 | |||
VMAT 2 Antibody (H-12) AC | sc-374079 AC | 500 µg/ml, 25% agarose | $416.00 | |||
VMAT 2 Antibody (H-12) HRP | sc-374079 HRP | 200 µg/ml | $316.00 | |||
VMAT 2 Antibody (H-12) FITC | sc-374079 FITC | 200 µg/ml | $330.00 | |||
VMAT 2 Antibody (H-12) PE | sc-374079 PE | 200 µg/ml | $343.00 | |||
VMAT 2 Antibody (H-12) Alexa Fluor® 488 | sc-374079 AF488 | 200 µg/ml | $357.00 | |||
VMAT 2 Antibody (H-12) Alexa Fluor® 546 | sc-374079 AF546 | 200 µg/ml | $357.00 | |||
VMAT 2 Antibody (H-12) Alexa Fluor® 594 | sc-374079 AF594 | 200 µg/ml | $357.00 | |||
VMAT 2 Antibody (H-12) Alexa Fluor® 647 | sc-374079 AF647 | 200 µg/ml | $357.00 | |||
VMAT 2 Antibody (H-12) Alexa Fluor® 680 | sc-374079 AF680 | 200 µg/ml | $357.00 | |||
VMAT 2 Antibody (H-12) Alexa Fluor® 790 | sc-374079 AF790 | 200 µg/ml | $357.00 |