Villin Antibody (G-6): sc-365310
- Villin Antibody (G-6) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 721-780 mapping near the C-terminus of Villin of human origin
- recommended for detection of Villin of human origin by WB, IP, IF, IHC(P) and ELISA
- See Villin (1D2C3): sc-58897 for Villin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Villin Antibody (G-6) for WB and IHC(P) applications. These reagents are now offered in bundles with Villin Antibody (G-6) (see ordering information below).
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Villin Antibody (G-6) is a mouse monoclonal IgG1 antibody that detects Villin in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Villin is a crucial actin-binding protein primarily found in the brush border of absorptive epithelial cells, where Villin plays a significant role in maintaining the structure and function of microvilli. Villin (G-6) antibody is essential for studying the organization of the cytoskeleton, contributing to cell shape and motility, which are vital for nutrient absorption in the intestines. Villin′s ability to regulate actin filament dynamics is influenced by calcium ions, highlighting Villin′s importance in cellular signaling pathways. Additionally, Villin undergoes post-translational modifications, such as phosphorylation, which can affect Villin′s activity and interactions with other proteins, further underscoring anti-Villin antibody (G-6)′s role in studying cellular processes. Villin monoclonal antibody (G-6) is an invaluable tool for researchers studying epithelial cell biology, cytoskeletal dynamics, and related pathologies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Villin Antibody (G-6) References:
- Immunoexpression of villin in neuroendocrine tumors and its diagnostic implications. | Zhang, PJ., et al. 1999. Arch Pathol Lab Med. 123: 812-6. PMID: 10458829
- Villin function in the organization of the actin cytoskeleton. Correlation of in vivo effects to its biochemical activities in vitro. | Friederich, E., et al. 1999. J Biol Chem. 274: 26751-60. PMID: 10480879
- Multistate folding of the villin headpiece domain. | Tang, Y., et al. 2006. J Mol Biol. 355: 1066-77. PMID: 16337228
- A novel role for villin in intestinal epithelial cell survival and homeostasis. | Wang, Y., et al. 2008. J Biol Chem. 283: 9454-64. PMID: 18198174
- Villin and actin in the mouse kidney brush-border membrane bind to and are degraded by meprins, an interaction that contributes to injury in ischemia-reperfusion. | Ongeri, EM., et al. 2011. Am J Physiol Renal Physiol. 301: F871-82. PMID: 21795642
- Functional comparison of villin and gelsolin. Effects of Ca2+, KCl, and polyphosphoinositides. | Janmey, PA. and Matsudaira, PT. 1988. J Biol Chem. 263: 16738-43. PMID: 2846546
- Sendai virus recruits cellular villin to remodel actin cytoskeleton during fusion with hepatocytes. | Chandra, S., et al. 2017. Mol Biol Cell. 28: 3801-3814. PMID: 29074568
- Heterogeneity in the Folding of Villin Headpiece Subdomain HP36. | Nagarajan, S., et al. 2018. J Phys Chem B. 122: 11640-11648. PMID: 30118232
- Evidence for the association of villin with core filaments and rootlets of intestinal epithelial microvilli. | Drenckhahn, D., et al. 1983. Cell Tissue Res. 228: 409-14. PMID: 6337719
- Targeted disruption of the mouse villin gene does not impair the morphogenesis of microvilli. | Pinson, KI., et al. 1998. Dev Dyn. 211: 109-21. PMID: 9438428
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Villin Antibody (G-6) | sc-365310 | 200 µg/ml | $322.00 | |||
Villin Antibody (G-6): m-IgG Fc BP-HRP Bundle | sc-537793 | 200 µg Ab; 10 µg BP | $361.00 | |||
Villin Antibody (G-6): m-IgGκ BP-HRP Bundle | sc-535184 | 200 µg Ab; 40 µg BP | $361.00 | |||
Villin Antibody (G-6): m-IgG1 BP-HRP Bundle | sc-545357 | 200 µg Ab; 20 µg BP | $361.00 |