Von Hippel Lindau/VHL Antibody (B-9): sc-514959
- Von Hippel Lindau/VHL Antibody (B-9) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 157-181 at the C-terminus of VHL of rat origin
- recommended for detection of VHL of mouse and rat origin by WB, IP, IF and ELISA
- See Von Hippel Lindau/VHL (D-7): sc-55506 for Von Hippel Lindau/VHL antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Von Hippel Lindau/VHL Antibody (B-9) for WB applications. These reagents are now offered in bundles with Von Hippel Lindau/VHL Antibody (B-9) (see ordering information below).
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SEE ALSO...
VHL Antibody (B-9) is a mouse monoclonal IgG1 antibody that detects von Hippel-Lindau (VHL) in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-VHL antibody (B-9) plays a crucial role in understanding the function of VHL, which is a key tumor suppressor involved in the regulation of hypoxia-inducible factors (HIFs). By targeting the Elongin (SIII) complex, VHL modulates the transcriptional activity of genes that respond to oxygen levels, thereby influencing cellular responses to hypoxia. This regulation is vital for maintaining cellular homeostasis and preventing tumorigenesis, as dysregulation of HIFs can lead to increased angiogenesis and tumor growth. The presence of different isoforms of VHL, which arise from alternatively spliced transcript variants, adds complexity to its function and regulation, as these isoforms may exhibit distinct roles in cellular processes. VHL monoclonal antibody (B-9) is an essential tool for researchers investigating the molecular mechanisms underlying VHL-related pathologies and the broader implications of hypoxia in cancer biology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Von Hippel Lindau/VHL Antibody (B-9) | sc-514959 | 200 µg/ml | $316.00 | |||
Von Hippel Lindau/VHL Antibody (B-9): m-IgG Fc BP-HRP Bundle | sc-541017 | 200 µg Ab; 10 µg BP | $354.00 | |||
Von Hippel Lindau/VHL Antibody (B-9): m-IgG1 BP-HRP Bundle | sc-542532 | 200 µg Ab; 20 µg BP | $354.00 | |||
Von Hippel Lindau/VHL (B-9) Neutralizing Peptide | sc-514959 P | 100 µg/0.5 ml | $68.00 |